Ketamine plus Alcohol: What We Know and What We Can Expect about This

被引：6

作者：

Correa Kobayashi, Natalia Harumi ^{[1
]}

Farias, Sarah Viana ^{[1
]}

Luz, Diandra Araujo ^{[1
]}

Machado-Ferraro, Kissila Marvia ^{[1
]}

da Conceicao, Brenda Costa ^{[1
]}

Menezes da Silveira, Cinthia Cristina ^{[1
]}

Pereira Fernandes, Luanna Melo ^{[1
]}

Cartagenes, Sabrina de Carvalho ^{[1
]}

Moraes Ferreira, Vania Maria ^{[2
]}

Fontes-Junior, Eneas Andrade ^{[1
]}

Ferraz Maia, Cristiane do Socorro ^{[1
]}

机构：

[1] Fed Univ Para, Fac Pharm, Inst Hlth Sci, Lab Pharmacol Inflammat & Behav, BR-66075110 Belem, Para, Brazil

[2] Univ Brasilia, Psychol Inst, Lab Psychobiol, Campus Univ Darcy Ribeiro Asa Norte, BR-70910900 Brasilia, DF, Brazil

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 14期

关键词：

ketamine; alcohol; drug abuse; addiction; toxicological effects; central nervous system; cardiorespiratory system; digestive system; renal system; CHRONIC ETHANOL EXPOSURE; NMDA RECEPTOR; URINARY-TRACT; NITRIC-OXIDE; K-HOLE; NEUROCOGNITIVE FUNCTION; PSYCHOTIC SYMPTOMS; RECREATIONAL USERS; DEPENDENT BLOCK; DRUG;

D O I：

10.3390/ijms23147800

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drug abuse has become a public health concern. The misuse of ketamine, a psychedelic substance, has increased worldwide. In addition, the co-abuse with alcohol is frequently identified among misusers. Considering that ketamine and alcohol share several pharmacological targets, we hypothesize that the consumption of both psychoactive substances may synergically intensify the toxicological consequences, both under the effect of drugs available in body systems and during withdrawal. The aim of this review is to examine the toxicological mechanisms related to ketamine plus ethanol co-abuse, as well the consequences on cardiorespiratory, digestive, urinary, and central nervous systems. Furthermore, we provide a comprehensive discussion about the probable sites of shared molecular mechanisms that may elicit additional hazardous effects. Finally, we highlight the gaps of knowledge in this area, which deserves further research.

引用

页数：45

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