The Expression and Clinical Significance of TGF-β1 and MMP2 in Human Renal Clear Cell Carcinoma

被引：15
|
作者：
Yang, Shu-dong [1 ]
Sun, Rong-chao [1 ]
Mu, Hui-jun [2 ]
Xu, Zhuo-qun [3 ]
Zhou, Zhi-yi [1 ]
机构：
[1] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Pathol, Wuxi 214023, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Wuxi Peoples Hosp, Cent Lab, Wuxi 214023, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Urol, Wuxi 214023, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2010年 / 18卷 / 02期
关键词：
renal clear cell carcinoma; TGF-beta; 1; MMP2; immunohistochemistry; reverse transcription-polymerase chain reaction; MATRIX-METALLOPROTEINASE EXPRESSION; TUMOR PROGRESSION; TGF-BETA; CANCER; GELATINASES; METASTASIS; ACTIVATION; PHENOTYPE; ANTIGENS; INVASION;
D O I：
10.1177/1066896909331993
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The expression and clinical significance of transforming growth factor beta 1 (TGF-beta 1) and matrix metalloproteinase-2 (MMP2) in human renal clear cell carcinoma (RCCC) were investigated. The intensity of TGF-beta 1 and MMP2 expression in RCCC kidneys was significantly higher than that in normal kidneys. Expression of TGF-beta 1 and MMP2 in RCCC tissues was positively correlated with pathological grade and clinical stage. There was also a significant correlation between TGF-beta 1 and Msshese analyses indicate that upregulation of TGF-beta 1 and MMP2 expression may occur during the progression of RCCC. Thus, TGF-beta 1 and MMP2 may be useful molecular markers for evaluating prognosis in RCCC patients.
引用
收藏
页码：85 / 93
页数：9
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