Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation

被引：347
|
作者：
Blackburn, C [1 ]
Guan, B [1 ]
Fleming, P [1 ]
Shiosaki, K [1 ]
Tsai, S [1 ]
机构：
[1] Millennium Pharmaceut, Drug Discovery, Cambridge, MA 02139 USA
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 22期
关键词：
D O I：
10.1016/S0040-4039(98)00653-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A three-component condensation reaction between 2-aminopyridine, an aldehyde and an isonitrile catalyzed by scandium triflate affords derivatives of 3-aminoimidazo[1,2-a]pyridine; aminopyrazine reacts similarly. A library of heterocycles, prepared in high yield by parallel synthesis and purification on an ion-exchange resin, was subjected to further reactions at the amino group. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3635 / 3638
页数：4
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