An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H2S Upregulation in Mice

被引：167
|
作者：
Chen, Zhongyan [1 ]
Mu, Xueling [3 ]
Han, Zhong [1 ]
Yang, Shiping [3 ]
Zhang, Changli [1 ]
Guo, Zijian [1 ,2 ]
Bai, Yang [1 ]
He, Weijiang [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, Coordinat Chem Inst, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ, Chem & Biomed Innovat Ctr, Nanjing 210023, Jiangsu, Peoples R China
[3] Shanghai Normal Univ, Key Lab Resource Chem, Shanghai 200234, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 45期
基金：
中国国家自然科学基金;
关键词：
HYDROGEN-SULFIDE; FLUORESCENCE PROBES; SIGNALING PATHWAYS; CANCER; NANOPROBE; STRATEGY; LEVEL; DYE;
D O I：
10.1021/jacs.9b09181
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was suggested for in/ex vivo H2S imaging. Therefore, a meso-benzoyloxyltricarboheptamethine cyanine, HS-CyBz, was prepared as the first ratiometric optical/PA dual-modality probe for H2S, profiting from a keto-enol transition sensing mechanism. Tail intravenous injection of this probe leads to probe accumulation in the liver of mice, and the endogenous H2S upregulation triggered by S-adenosyl-l-methionine has been verified by ratiometric optical/PA imaging, suggesting the promising potential of this ratiometric dual-modality imaging.
引用
收藏
页码：17973 / 17977
页数：5
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