Persistent anxiety-like behavior in mannosets following a recent predatory stress condition: Reversal by diazepam

被引:20
|
作者
Barros, Marilia [1 ]
Giorgetti, Marco
Vieira Souto, Anna America
Vilela, Gabriela
Santos, Katarina
Vilas Boas, Naia
Tomaz, Carlos
机构
[1] Univ Brasilia, Sch Hlth Sci, Primate Ctr, BR-70910900 Brasilia, DF, Brazil
[2] Univ Brasilia, Sch Hlth Sci, Dept Pharmaceut Sci, BR-70910900 Brasilia, DF, Brazil
[3] Amgen Inc, San Francisco, CA 94080 USA
[4] Univ Brasilia, Inst Biol, Primate Ctr, Brasilia, DF, Brazil
[5] Univ Brasilia, Inst Biol, Lab Neurosci & Behav, Brasilia, DF, Brazil
关键词
marmosets; predatory stress; defensive behavior; fear; anxiety; diazepam;
D O I
10.1016/j.pbb.2007.02.016
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Initial investigations indicated the use of the Marmoset Predator Confrontation Test (MPCT) as an experimental procedure to measure fear/anxiety-related behaviors in non-human primates. However, possible long-term habituation effects and re-use of experimental subjects need to be verified. This study, therefore, compared the behavioral response of experienced versus naive adult black tufted-ear marmosets (Callithrix penicillata) in the MPCT, with/without diazepam administrations. Subjects were tested in the figure-8 maze and confronted with a taxidermized wild-cat predator stimulus. After four initial 20-min maze habituation sessions, each subject was submitted to two randomly-assigned 20-min predator confrontation sessions: vehicle and 2 mg/kg of diazepam. Confrontation with the predator induced significant behavioral changes; i.e., proximic avoidance and tsik-tsik alarm call. Diazepam administration, concomitant to predator exposure, reversed the behavioral changes observed. In both the experienced and naive marmosets a similar behavioral profile and response pattern to diazepam was detected, corroborating the important selective pressure that felines seem to have on marmoset behavioral ecology. Therefore, during a more naturalistic-like regimen i.e., recurring intermittent predator encounters - the general response pattern remains highly consistent, regardless of prior experience. One may consider the re-use of marmoset subjects in the MPCT, particularly under these specific conditions (i.e. repeated 20-min confrontations, 72-h apart). (c) 2007 Elsevier Inc. All tights reserved.
引用
收藏
页码:705 / 711
页数:7
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