Genomic analysis of the eukaryotic protein kinase superfamily: a perspective

被引:216
|
作者
Hanks, SK [1 ]
机构
[1] Vanderbilt Univ, Sch Med, Dept Cell & Dev Biol, Nashville, TN 37232 USA
关键词
D O I
10.1186/gb-2003-4-5-111
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Protein kinases with a conserved catalytic domain make up one of the largest 'superfamilies' of eukaryotic proteins and play many key roles in biology and disease. Efforts to identify and classify all the members of the eukaryotic protein kinase superfamily have recently culminated in the mining of essentially complete human genome data.
引用
收藏
页数:7
相关论文
共 50 条
  • [41] Characterization of a eukaryotic type serine/threonine protein kinase and protein phosphatase of Streptococcus pneumoniae and identification of kinase substrates
    Nováková, L
    Sasková, L
    Pallová, P
    Janecek, J
    Novotná, J
    Ulrych, A
    Echenique, J
    Trombe, MC
    Branny, P
    FEBS JOURNAL, 2005, 272 (05) : 1243 - 1254
  • [42] A genomic perspective of protein kinases in Plasmodium falciparum
    Anamika
    Srinivasan, N
    Krupa, A
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 58 (01) : 180 - 189
  • [43] Early diversification of the TNF superfamily in teleosts: Genomic characterization and expression analysis
    Glenney, Gavin W.
    Wiens, Gregory D.
    JOURNAL OF IMMUNOLOGY, 2007, 178 (12): : 7955 - 7973
  • [44] Functional genomic analysis of stress-activated protein kinase signalling pathways.
    Moggs, JG
    Hollis, A
    Hazzalin, CA
    Thomson, S
    Mahadevan, LC
    Kimber, I
    Orphanides, G
    TOXICOLOGICAL SCIENCES, 2003, 72 : 63 - 63
  • [45] Dusty protein kinase interacts directly with Keap1, a member of the Kelch protein superfamily
    Dong, WJ
    Peng, JB
    Huang, CH
    FASEB JOURNAL, 2006, 20 (04): : A104 - A104
  • [46] Homologs of eukaryotic Ras superfamily proteins in prokaryotes and their novel phylogenetic correlation with their eukaryotic analogs
    Dong, Jiu-Hong
    Wen, Jian-Fan
    Tian, Hai-Feng
    GENE, 2007, 396 (01) : 116 - 124
  • [47] A HEAT-SHOCK PROTEIN LOCALIZED TO CHLOROPLASTS IS A MEMBER OF A EUKARYOTIC SUPERFAMILY OF HEAT-SHOCK PROTEINS
    VIERLING, E
    NAGAO, RT
    DEROCHER, AE
    HARRIS, LM
    EMBO JOURNAL, 1988, 7 (03): : 575 - 581
  • [48] Elongation factor-2 kinase: A novel eukaryotic protein kinase as a therapeutic target.
    Arora, S
    Vizel, A
    Robinson, V
    Yang, J
    Stock, A
    Hait, WN
    CLINICAL CANCER RESEARCH, 2001, 7 (11) : 3687S - 3687S
  • [49] Protein targeting of an unusual, evolutionarily conserved adenylate kinase to a eukaryotic flagellum
    Pullen, TJ
    Ginger, ML
    Gaskell, SJ
    Gull, K
    MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (07) : 3257 - 3265
  • [50] IDENTIFICATION OF A EUKARYOTIC-LIKE PROTEIN-KINASE GENE IN ARCHAEBACTERIA
    SMITH, RF
    KING, KY
    PROTEIN SCIENCE, 1995, 4 (01) : 126 - 129