Modulation of thermal pain-related brain activity with virtual reality: evidence from fMRI

被引：223

作者：

Hoffman, HG

Richards, TL

Coda, B

Bills, AR

Blough, D

Richards, AL

Sharar, SR

机构：

[1] Univ Washington, Human Interface Technol Lab, Seattle, WA 98195 USA

[2] Univ Washington, Dept Radiol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Pharm, Seattle, WA 98195 USA

[4] Univ Washington, Dept Anesthesiol, Seattle, WA 98104 USA

来源：

NEUROREPORT | 2004年 / 15卷 / 08期

关键词：

analgesia; anterior cingulate cortex; fMRI; pain; somatosensory cortex; virtual reality;

D O I：

10.1097/01.wnr.0000127826.73576.91

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigated the neural correlates of virtual reality analgesia. Virtual reality significantly reduced subjective pain ratings (i.e. analgesia). Using fMRI, pain-related brain activity was measured for each participant during conditions of no virtual reality and during virtual reality (order randomized). As predicted, virtual reality significantly reduced pain-related brain activity in all five regions of interest; the anterior cingulate cortex, primary and secondary somatosensory cortex, insula, and thalamus (p<0.002, corrected). Results showed direct modulation of human brain pain responses by virtual reality distraction.

引用

页码：1245 / 1248

页数：4

共 50 条

[1] Pain sensitivity and fMRI pain-related brain activity in Alzheimer's disease
Cole, Leonie J.
Farrell, Michael J.
Duff, Eugene P.
Barber, J. Bruce
Egan, Gary F.
Gibson, Stephen J.
BRAIN, 2006, 129 : 2957 - 2965
[2] Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans
Iannetti, GD
Zambreanu, L
Wise, RG
Buchanan, TJ
Huggins, JP
Smart, TS
Vennart, W
Tracey, I
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (50) : 18195 - 18200
[3] USING VIRTUAL REALITY TO ASSESS PAIN-RELATED ALTERATIONS IN BODY AND MOVEMENT PERCEPTION
Mercier, Catherine
PSYCHOPHYSIOLOGY, 2018, 55 : S14 - S14
[4] EXAMINING VIRTUAL REALITY GAMING FOR PAIN-RELATED FEAR AND DISABILITY IN CHRONIC LOW BACK PAIN
Nowlin, Liza
Madi, Dina
Guck, Adam
Davis, Madison
Trost, Zina
ANNALS OF BEHAVIORAL MEDICINE, 2015, 49 : S116 - S116
[5] Cognitive modulation of pain-related brain responses depends on behavioral strategy
Seminowicz, DA
Mikulis, DJ
Davis, KD
PAIN, 2004, 112 (1-2) : 48 - 58
[6] Test-Retest Reliability of Pain-Related Brain Activity in Healthy Controls Undergoing Experimental Thermal Pain
Letzen, Janelle E.
Sevel, Landrew S.
Gay, Charles W.
O'Shea, Andrew M.
Craggs, Jason G.
Price, Donald D.
Robinson, Michael E.
JOURNAL OF PAIN, 2014, 15 (10): : 1008 - 1014
[7] Modulation of cold pain in human brain by electric acupoint stimulation: evidence from fMRI
Zhang, WT
Jin, Z
Huang, J
Zhang, L
Zeng, YW
Luo, F
Chen, ACN
Han, JS
NEUROREPORT, 2003, 14 (12) : 1591 - 1596
[8] Music Modulation of Pain Perception and Pain-Related Activity in the Brain, Brain Stem, and Spinal Cord: A Functional Magnetic Resonance Imaging Study
Dobek, Christine E.
Beynon, Michaela E.
Bosma, Rachael L.
Stroman, Patrick W.
JOURNAL OF PAIN, 2014, 15 (10): : 1057 - 1068
[9] Effects of azapropazone on pain-related brain activity in human subjects
Lotsch, J
MOhammadian, P
Hummel, T
Florin, S
Brune, K
Geisslinger, G
Kobal, G
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1995, 40 (06) : 545 - 552
[10] Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study
Tsuji, Toshio
Arikuni, Fumiya
Sasaoka, Takafumi
Suyama, Shin
Akiyoshi, Takashi
Soh, Zu
Hirano, Harutoyo
Nakamura, Ryuji
Saeki, Noboru
Kawamoto, Masashi
Yoshizumi, Masao
Yoshino, Atsuo
Yamawaki, Shigeto
SCIENTIFIC REPORTS, 2021, 11 (01)

← 1 2 3 4 5 →