Topology Optimization of Three-Dimensional Biodegradable Polymer Multi-layer Microstructure for Implantable Drug Controlled Release

被引：0
|
作者：
Yu, Ruixia [1 ]
Chen, Hualing [1 ]
Zhou, Xiangyang [1 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Mech Engn, Xian 710049, Peoples R China
来源：
ADVANCED MATERIALS AND PROCESSING | 2007年 / 26-28卷
关键词：
Biodegradable polymer; Topology optimization; drug controlled release; microstructure;
D O I：
10.4028/www.scientific.net/AMR.26-28.757
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Biodegradable polymer multi-layer drug delivery microstructure with micro-chambers has some unique advantages in controlled long-term drug delivery, which can enclose drug in the chambers to realize drug release in a controlled fashion. Therefore, it is necessary to obtain the optimal designs of the micro-chambers and their distributions. In this paper, topology optimization of a three-dimensional biodegradable polymer multi-layer drug delivery microstructure was carried out using the cellular automaton (CA)-based evolutionary structural optimization method. The results show that the optimized controlled release system exhibits a preferable linear drug release profile.
引用
收藏
页码：757 / +
页数：5
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