Use of Lactose against the Deadly Biological Toxin Ricin

被引：22
|
作者：
Nagatsuka, Takehiro [1 ]
Uzawa, Hirotaka [1 ]
Ohsawa, Isaac [2 ]
Seto, Yasuo [2 ]
Nishida, Yoshihiro [3 ]
机构：
[1] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058565, Japan
[2] Natl Res Inst Police Sci, Kashiwa, Chiba 2770882, Japan
[3] Chiba Univ, Fac Hort, Matsudo, Chiba 2718510, Japan
来源：
ACS APPLIED MATERIALS & INTERFACES | 2010年 / 2卷 / 04期
关键词：
glycopolymer; biological toxin; decontamination; ricin; terrorism; GLYCOPOLYMERS; COPOLYMERIZATION; INHIBITION;
D O I：
10.1021/am900846r
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Developing a technology for detecting and decontaminating biological toxins is needed. Ricin from Ricinus communis is a highly poisonous toxin; it was formerly used for an assassination in London and in postal attacks in the United States. Ricin is readily available From castor beans and could be used as a biological agent. We propose using glycotechnology against the illegal use of ricin. Lactose (a natural ligand of this toxin) was incorporated into polyacrylamide-based glycopolymers at variable sugar densities (18-100%) and evaluated with surface plasmon resonance (SPR) spectroscopy and the real agent, ricin. Glycopolymers (18-65% lactose densities) effectively interfered with the toxin-lactoside adhesion event (>99% efficiency within 20 min). This supported the notion of using the mammary sugar lactose against a deadly biological toxin.
引用
收藏
页码：1081 / 1085
页数：5
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