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Successful treatment of pure red cell aplasia after major ABO-incompatible T cell-depleted bone marrow transplantation with erythropoietin
被引:33
|作者:
Santamaría, A
[1
]
Sureda, A
[1
]
Martino, R
[1
]
Domingo-Albós, A
[1
]
Muñiz-Díaz, E
[1
]
Brunet, S
[1
]
机构:
[1] Hosp Santa Creu & Sant Pau, Dept Hematol, Unitat Hematol Clin, Barcelona 08025, Spain
关键词:
ABO-incompatible BMT;
erythropoietin;
pure red cell aplasia;
D O I:
10.1038/sj.bmt.1701012
中图分类号:
Q6 [生物物理学];
学科分类号:
071011 ;
摘要:
A 40-year-old woman with acute myeloid leukemia in first remission developed pure red cell aplasia after a T cell-depleted ABO-incompatible bone marrow transplant from her HLA-identical sister. She remained transfusion-dependent for 11 months despite conversion of the ABO blood group to donor type, and titers of anti-donor isohemagglutinin being undetectable. Treatment with erythropoietin resulted in rapid improvement of the anemia with no further need for transfusions up to 21 months post-transplant. This case suggests that erythropoietin may provide effective therapy for pure red cell aplasia after ABO-incompatible bone marrow transplantation without the additional risks of further immunosuppression.
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页码:1105 / 1107
页数:3
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