Successful treatment of pure red cell aplasia after major ABO-incompatible T cell-depleted bone marrow transplantation with erythropoietin

被引:33
|
作者
Santamaría, A [1 ]
Sureda, A [1 ]
Martino, R [1 ]
Domingo-Albós, A [1 ]
Muñiz-Díaz, E [1 ]
Brunet, S [1 ]
机构
[1] Hosp Santa Creu & Sant Pau, Dept Hematol, Unitat Hematol Clin, Barcelona 08025, Spain
关键词
ABO-incompatible BMT; erythropoietin; pure red cell aplasia;
D O I
10.1038/sj.bmt.1701012
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
A 40-year-old woman with acute myeloid leukemia in first remission developed pure red cell aplasia after a T cell-depleted ABO-incompatible bone marrow transplant from her HLA-identical sister. She remained transfusion-dependent for 11 months despite conversion of the ABO blood group to donor type, and titers of anti-donor isohemagglutinin being undetectable. Treatment with erythropoietin resulted in rapid improvement of the anemia with no further need for transfusions up to 21 months post-transplant. This case suggests that erythropoietin may provide effective therapy for pure red cell aplasia after ABO-incompatible bone marrow transplantation without the additional risks of further immunosuppression.
引用
收藏
页码:1105 / 1107
页数:3
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