Profile of MicroRNA Expression in Brain Tumors of Different Malignancy

被引：12
|
作者：
Koshkin, F. A. [1 ,2 ]
Chistyakov, D. A. [1 ]
Nikitin, A. G. [1 ]
Konovalov, A. N. [3 ]
Potapov, A. A. [3 ]
Usachyov, D. Yu. [3 ]
Pitskhelauri, D. I. [3 ]
Kobyakov, G. L. [3 ]
Shishkina, L. V. [3 ]
Chekhonin, V. P.
机构：
[1] NI Pirogov Russian Res Med Univ, Minist Hlth Russian Federat, Dept Med Nanobiotechnol, Moscow, Russia
[2] Minist Hlth Russian Federat, VP Serbsky Ctr Social & Forens Psychiat, Dept Basic & Appl Neurobiol, Moscow, Russia
[3] Russian Acad Med Sci, NN Burdenko Inst Neurosurg, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 06期
关键词：
microRNA; brain tumors; glioma; diagnosis; expression; GLIOBLASTOMA; THERAPY; PCR;
D O I：
10.1007/s10517-014-2669-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The expression profiles of 10 mature microRNA (7, 10a, 17, 20a, 21, 23a, 26a, 137, 222) in biopsy specimens of gliomas of different malignancy were studied by the real time PCR with SYBR Green I fluorescent stain. The expression of microRNA-21 increased significantly, while that of microRNA-137 decreased, depending on the tumor malignancy. The expression of microRNA-9, -17, -20a, -23a, -26a was significantly higher, while that of microRNA-7 lower in the tumor vs. control tissue samples. New data on the molecular pathological mechanisms of gliomas related to their malignancy were obtained. Quantitative analysis of microRNA was suggested as a potential diagnostic marker of brain tumors.
引用
收藏
页码：794 / 797
页数：4
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