Metallosurfactants C n -Cu-C n : vesicle formation and its drug-controlled release properties

被引：18

作者：

Zha, Quanwen ^{[1
]}

Xie, Qiulan ^{[1
]}

Hu, Yimin ^{[1
]}

Han, Jie ^{[1
]}

Ge, Lingling ^{[1
]}

Guo, Rong ^{[1
]}

机构：

[1] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

来源：

COLLOID AND POLYMER SCIENCE | 2016年 / 294卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Metallosurfactants; Vesicle; Drug carrier; Doxorubicin hydrochloride; Controlled release; CATIONIC SURFACTANT; FTIR SPECTROSCOPY; DELIVERY SYSTEM; PH; TEMPERATURE; COMPLEXES; COPOLYMER; BEHAVIOR; SULFATE; CANCER;

D O I：

10.1007/s00396-016-3841-7

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Three metallosurfactants C (n) -Cu-C (n) (n = 8, 12, 16) were synthesized via two-step in this paper. All of these surfactants were characterized by ultimate analysis, H-1 NMR, FT-IR, LC-MS, elemental analysis. In addition, the three surfactants can form vesicles under sonication at a relatively high concentration, and their aggregation behavior and the stability of C (n) -Cu-C (n) vesicles were investigated by surface tension, electrical conductivity, FT-IR, negative staining-TEM. Results showed that C-12-Cu-C-12 vesicles with average size of similar to 60 nm had good stability over inorganic salt, temperature, and aging time. Doxorubicin hydrochloride was incorporated into C-12-Cu-C-12 vesicles with a remarkably high efficiency of above 70 %, and the delivery system has obvious sustained release effect.

引用

页码：841 / 849

页数：9

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