Nickel-Catalyzed Asymmetric [2+2] Cycloaddition Reaction of Hetero-Bicyclic Alkenes with Internal Alkynes

被引：27
|
作者：
Qin, Hongyu [1 ]
Chen, Jingchao [1 ]
Li, Kangkui [1 ]
He, Zhenxiu [1 ]
Zhou, Yongyun [1 ]
Fan, Baomin [1 ,2 ]
机构：
[1] Yunnan Minzu Univ, YMU HKBU Joint Lab Tradit Nat Med, Yuehua St, Kunming 650500, Yunnan, Peoples R China
[2] Key Lab Chem Ethn Med Resources, Yuehua St, Kunming 650500, Yunnan, Peoples R China
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2018年 / 13卷 / 17期
基金：
中国国家自然科学基金;
关键词：
alkynes; asymmetric catalysis; azabenzonorbornadiene; cycloaddition; oxabenzonorbornadiene; RING-OPENING REACTIONS; OXABICYCLIC ALKENES; RUTHENIUM(II)-CATALYZED CYCLIZATION; CYCLOBUTANE DERIVATIVES; PHOSPHORUS LIGANDS; ORGANIC-SYNTHESIS; HYDROGENATION; ACID; AZABENZONORBORNADIENES; ALCOHOLS;
D O I：
10.1002/asia.201800492
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Enantioselective [2+2] cycloaddition reaction of azabenzonorbornadienes and oxabenzonorbornadienes with internal alkynes has been enabled by a catalyst system comprising Ni(COD)(2) and (R)-SIPHOS-Ph-Mor. This transformation represents the first asymmetric [2+2] cycloaddition reaction of azabenzonorbornadienes with internal alkynes, providing a straightforward method to prepare four-membered carbocycles.
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页码：2431 / 2434
页数：4
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