Nickel-Catalyzed Asymmetric [2+2] Cycloaddition Reaction of Hetero-Bicyclic Alkenes with Internal Alkynes

被引：27

作者：

Qin, Hongyu ^{[1
]}

Chen, Jingchao ^{[1
]}

Li, Kangkui ^{[1
]}

He, Zhenxiu ^{[1
]}

Zhou, Yongyun ^{[1
]}

Fan, Baomin ^{[1
,2
]}

机构：

[1] Yunnan Minzu Univ, YMU HKBU Joint Lab Tradit Nat Med, Yuehua St, Kunming 650500, Yunnan, Peoples R China

[2] Key Lab Chem Ethn Med Resources, Yuehua St, Kunming 650500, Yunnan, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2018年 / 13卷 / 17期

基金：

中国国家自然科学基金;

关键词：

alkynes; asymmetric catalysis; azabenzonorbornadiene; cycloaddition; oxabenzonorbornadiene; RING-OPENING REACTIONS; OXABICYCLIC ALKENES; RUTHENIUM(II)-CATALYZED CYCLIZATION; CYCLOBUTANE DERIVATIVES; PHOSPHORUS LIGANDS; ORGANIC-SYNTHESIS; HYDROGENATION; ACID; AZABENZONORBORNADIENES; ALCOHOLS;

D O I：

10.1002/asia.201800492

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective [2+2] cycloaddition reaction of azabenzonorbornadienes and oxabenzonorbornadienes with internal alkynes has been enabled by a catalyst system comprising Ni(COD)(2) and (R)-SIPHOS-Ph-Mor. This transformation represents the first asymmetric [2+2] cycloaddition reaction of azabenzonorbornadienes with internal alkynes, providing a straightforward method to prepare four-membered carbocycles.

引用

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页码：2431 / 2434

页数：4

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