Lipid balance in rats with fluoride-induced hyperglycemia

Fourteen-week-old male Wistar FL strain rats were administered sodium fluoride in a single intraperitoneal dose (35 mg NaF/kg bw) and after 90 min were fatally anesthetized. In a separate experiment, four-week-old male rats of the same strain were given fluoride in their drinking water (50 or 100 mg F-/L) for four months and then anesthetized. Both experiments produced hyperglycemia, accompanied by a statistically significant increase in the concentrations of fluoride in the blood serum. Hypertriacylglycerolemia also occurred in the long-term intoxication experiment, thereby indicating disturbances of lipid metabolism under the influence of NaF, which are similar to those observed in diabetes mellitus or in starvation.