Preparation of useful synthetic intermediates of taxol analogs, cyclooctenone derivatives

被引：0

作者：

Yamada, K ^{[1
]}

Tozawa, T ^{[1
]}

Saitoh, K ^{[1
]}

Mukaiyama, T ^{[1
]}

机构：

[1] Sci Univ Tokyo, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 162, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1997年 / 45卷 / 12期

关键词：

cyclooctenone; samarium(II) iodide; omega-(alpha-bromoketo) aldehyde; deoxygenated taxane framework;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stereoselective syntheses of omega-(alpha-bromoketo) octanals and nonanal with oxygenated functions and formation of the corresponding eight-membered carbocyclic aldols by subsequent samarium(II)-mediated cyclization are demonstrated. Cyclooctenones deoxygenated at the C2 or C10 position in the taxane framework are prepared by dehydration of the above aldols.

引用

页码：2113 / 2115

页数：3

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