Generation and characterization of a human induced pluripotent stem cell line UOWi005-A from dermal fibroblasts derived from a CCNFS621G familial amyotrophic lateral sclerosis patient using mRNA reprogramming

被引：8
|
作者：
Bax, Monique [1 ,2 ]
Balez, Rachelle [1 ,2 ]
Munoz, Sonia Sanz [1 ,2 ]
Do-Ha, Dzung [1 ,2 ]
Stevens, Claire H. [1 ,2 ]
Berg, Tracey [1 ,2 ]
Cabral-da-Silva, Mauricio C. [1 ,2 ]
Engel, Martin [1 ,2 ]
Nicholson, Garth [3 ]
Yang, Shu [4 ]
Blair, Ian P. [4 ]
Ooi, Lezanne [1 ,2 ]
机构：
[1] Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia
[2] Univ Wollongong, Sch Chem & Mol Biosci, Wollongong, NSW 2522, Australia
[3] Univ Sydney, Concord Repatriat Gen Hosp, ANZAC Res Inst, Sydney, NSW, Australia
[4] Macquarie Univ, Fac Med & Hlth Sci, Macquarie Univ Ctr Motor Neuron Dis Res, N Ryde, NSW 2109, Australia
来源：
STEM CELL RESEARCH | 2019年 / 40卷
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
D O I：
10.1016/j.scr.2019.101530
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Dermal fibroblasts from a 59 year old male patient with amyotrophic lateral sclerosis (symptomatic at the time of collection), attributed to a mutation in the cyclin F gene (CCNFS621G), were reprogrammed using mRNA and microRNA-delivered OSKM factors to induced pluripotent stem cells (iPSCs). The generated iPSCs were confirmed pluripotent, expressing typical pluripotency markers and were capable of three germ layer differentiation. This is the first reported reprogramming of cells with a mutation in the cyclin F gene, and represents a novel resource for the study of amyotrophic lateral sclerosis.
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页数：4
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