Procyanidins Extracted From the Lotus Seedpod Ameliorate Age-Related Antioxidant Deficit in Aged Rats

被引：38
|
作者：
Xu, Jiqu [1 ,2 ]
Rong, Shuang [1 ,2 ]
Xie, Bijun [3 ]
Sun, Zhida [3 ]
Zhang, Li [4 ]
Wu, Hailei [1 ,2 ]
Yao, Ping [1 ,2 ]
Hao, Liping [1 ,2 ]
Liu, Liegang [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Wuhan 430030, Peoples R China
[3] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Neurol, Wuhan 430030, Peoples R China
来源：
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2010年 / 65卷 / 03期
关键词：
Procyanidins; Aging; Oxidative stress; Lipid peroxidation; Antioxidant enzymes; LIPID-PEROXIDATION; OXIDATIVE DAMAGE; PROANTHOCYANIDINS; GLUTATHIONE; CATALASE; TISSUES; GENERATION; DISMUTASE; ENZYMES; SYSTEMS;
D O I：
10.1093/gerona/glp211
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The alleviative effect of procyanidins extracted from the lotus seedpod (LSPC) on oxidative stress in various tissues was evaluated by determining the activities of the antioxidant enzymes and the content of reduced glutathione (GSH) in heart, liver, lung, kidney. skeletal muscle, and serum in aged rats. Aging led to antioxidant deficit in various tissues in this study, which is confirmed by remarkable increased lipid peroxidation, whereas the change patterns of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and GSH were diverse in various tissues of aged rats. LSPC treatment (50 and 100 mg/kg body weight) modified the activity of SOD, CAT. and GPx as well as GSH content alteration in these tissues, which reversed the age-related antioxidant deficit in aged rats. However, the regulatory patterns on the activities of these enzymes and GSH content by LSPC treatment were different according to the tissues in aged rats.
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页码：236 / 241
页数：6
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