Efficient palladium-catalyzed synthesis of unsymmetrical (het)aryltetrazines

被引：35
|
作者：
Leconte, Nicolas
Keromnes-Wuillaume, Anne
Suzenet, Franck
Guillaumet, Gerald
机构：
[1] Univ Orleans, Inst Chim Organ & Analyt, UMR 6005, F-45067 Orleans, France
[2] CEA Le Ripault, F-37260 Monts, France
来源：
SYNLETT | 2007年 / 02期
关键词：
3-methylthio-1,2,4,5-tetrazine; Pd-catalyzed; Cu(I)assisted; Suzuki-like reactions; Stille-like reactions;
D O I：
10.1055/s-2007-96799
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed copper(I)-mediated cross-coupling reaction of 3-methylthio-6-(morpholin-4-yl)-1,2,4,5-tetrazine with a wide range of boronic acids and organotin derivatives led to new unsymmetrical aryl- and hetaryl-substituted tetrazines in moderate to good yields. These results represent the first cross-coupling reactions of readily available 3-methylthiotetrazine under Suzuki-like and Stille-like conditions and could extend the scope of tetrazine chemistry.
引用
收藏
页码：204 / 210
页数：7
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