Characteristics of patients with bronchoscopy-diagnosed pulmonary Mycobacterium avium complex infection
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Urabe, Naohisa
[1
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Sakamoto, Susumu
[1
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Sano, Go
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Toho Univ, Omori Med Ctr, Dept Resp Med, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438540, JapanToho Univ, Omori Med Ctr, Dept Resp Med, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438540, Japan
Sano, Go
[1
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Ito, Ai
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Toho Univ, Omori Med Ctr, Dept Resp Med, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438540, JapanToho Univ, Omori Med Ctr, Dept Resp Med, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438540, Japan
Ito, Ai
[1
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Homma, Sakae
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Toho Univ, Omori Med Ctr, Dept Resp Med, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438540, JapanToho Univ, Omori Med Ctr, Dept Resp Med, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438540, Japan
Homma, Sakae
[1
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[1] Toho Univ, Omori Med Ctr, Dept Resp Med, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438540, Japan
Background: We occasionally treat patients with clinically suspected pulmonary Mycobacterium avium complex (MAC) infection and negative MAC culture on bronchoscopy. Objective: This study aimed to investigate the usefulness of bronchoscopy in patients with suspected MAC lung disease with nodular bronchiectasis on chest computed tomography (CT) and to clarify the clinical characteristics of these patients. Methods: We reviewed the records of 71 patients with clinically suspected pulmonary MAC infection on chest CT who underwent bronchoscopy. The patients were classified on the basis of MAC culture result, and their clinical characteristics were compared. Results: MAC was detected in 33 of the 71 (46.5%) patients (positive group), and 35 (49.3%) were culture-negative for nontuberculous mycobacteria (NTM) (negative group). NTM other than MAC were detected in 3 of 71 (4.2%) patients. MAC was not detected in 14 of 38 (36.8%) patients positive for GPL core IgA antibody. Patients in the positive group had a higher body mass index (20.1 +/- 3.4 vs 18.5 +/- 2.9 kg/m(2); p = 0.047) and positive rate for GPL core IgA antibody (72.7% vs 40%; p = 0.006) and a lower chronic obstructive pulmonary disease assessment test score (6.6 +/- 6.6 vs 11.7 +/- 8.5; p = 0.016) and rate of positive culture for Pseudomonas aeruginosa or Haemophilus influenzae (12.1% vs 45.7%; p = 0.003), as compared with the negative group. Conclusion: Bronchoscopy is useful for diagnosis of MAC in patients who cannot be diagnosed by sputum examination. In addition, patients with pulmonary MAC disease had less severe subjective symptoms and weight loss than did those with a negative MAC culture on bronchoscopy. (C) 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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Toranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
Okinaka Mem Inst Med Res, Tokyo, JapanToranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
Uruga, Hironori
Suzuki, Aika
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Toranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, JapanToranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
Suzuki, Aika
Hanada, Shigeo
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Toranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, JapanToranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
Hanada, Shigeo
Takaya, Hisashi
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Toranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, JapanToranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
Takaya, Hisashi
Miyamoto, Atsushi
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Toranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, JapanToranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
Miyamoto, Atsushi
Morokawa, Nasa
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Toranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, JapanToranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
Morokawa, Nasa
Fujii, Takeshi
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Toranomon Gen Hosp, Dept Pathol, Tokyo, Japan
Okinaka Mem Inst Med Res, Tokyo, JapanToranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
Fujii, Takeshi
Kurosaki, Atsuko
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Toranomon Gen Hosp, Dept Diagnost Radiol, Tokyo, JapanToranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
Kurosaki, Atsuko
Kishi, Kazuma
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Toranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
Okinaka Mem Inst Med Res, Tokyo, JapanToranomon Gen Hosp, Dept Resp Med, Resp Ctr, Tokyo, Japan
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Tokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, JapanTokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, Japan
Koyama, Kazuya
Ohshima, Nobuharu
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Tokyo Natl Hosp, Natl Hosp Org, Ctr Asthma & Allergy, Tokyo, JapanTokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, Japan
Ohshima, Nobuharu
Kawashima, Masahiro
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Tokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, JapanTokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, Japan
Kawashima, Masahiro
Okuda, Kenichi
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Tokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, JapanTokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, Japan
Okuda, Kenichi
Sato, Ryota
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Tokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, JapanTokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, Japan
Sato, Ryota
Nagai, Hideaki
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Tokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, JapanTokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, Japan
Nagai, Hideaki
Matsui, Hirotoshi
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Tokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, JapanTokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, Japan
Matsui, Hirotoshi
Ohta, Ken
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Tokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, Japan
Tokyo Natl Hosp, Natl Hosp Org, Ctr Asthma & Allergy, Tokyo, JapanTokyo Natl Hosp, Natl Hosp Org, Ctr Pulm Dis, Tokyo, Japan
机构:
Lankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Lankenau Inst Med Res, Wynnewood, PA 19096 USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Lande, Leah
Whealon, Spencer
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Lankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Whealon, Spencer
Singer, Eden
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Lankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Singer, Eden
Greenspon, Lee W.
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Lankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Greenspon, Lee W.
Rains, Erin
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Lankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Rains, Erin
Kwait, Rebecca
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Lankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Kwait, Rebecca
Buckley, Meghan
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Lankenau Inst Med Res, Wynnewood, PA 19096 USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Buckley, Meghan
Peng, Weidan
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Lankenau Inst Med Res, Wynnewood, PA 19096 USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Peng, Weidan
Sawicki, Janet
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Lankenau Inst Med Res, Wynnewood, PA 19096 USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Sawicki, Janet
Falkinham III, Joseph O.
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机构:
Virginia Tech, Dept Biol Sci, Blacksburg, VA USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Falkinham III, Joseph O.
Williams, Myra D.
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Virginia Tech, Dept Biol Sci, Blacksburg, VA USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA
Williams, Myra D.
Peterson, Donald D.
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机构:
Lankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USALankenau Med Ctr, Div Pulm & Crit Care Med, Wynnewood, PA 19096 USA