Catalytic Asymmetric Total Synthesis of Tangutorine

被引：25

作者：

Nemoto, Tetsuhiro ^{[1
]}

Yamamoto, Eri ^{[1
]}

Franzen, Robert ^{[1
]}

Fukuyama, Takashi ^{[1
]}

Wu, Riliga ^{[1
]}

Fukamachi, Toshihiko ^{[1
]}

Kobayashi, Hiroshi ^{[1
]}

Hamada, Yasumasa ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 04期

关键词：

CHIROGENIC DIAMINOPHOSPHINE OXIDES; STEREOSELECTIVE TOTAL-SYNTHESIS; ALLYLIC SUBSTITUTION; PALLADIUM; DIAPHOXS; ACID; (+/-)-TANGUTORINE; NUCLEOPHILES; DERIVATIVES; CYCLIZATION;

D O I：

10.1021/ol902929a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first enantioselective total synthesis of tangutorine has been achieved, wherein a Pd-catalyzed asymmetric allylic amination using a chiral diaminophosphine oxide (DIAPHOX) preligand was the key step.

引用

页码：872 / 875

页数：4

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