Synthesis of bis(indolyl)methanes catalyzed by acidic ionic liquid immobilized on silica (ILIS)

被引：68
|
作者：
Hagiwara, Hisahiro
Sekifuji, Masayoshi
Hoshi, Takashi
Qiao, Kun
Yokoyama, Chiaki
机构：
[1] Niigata Univ, Grad Sch Sci & Technol, Niigata 9502181, Japan
[2] Niigata Univ, Fac Engn, Niigata 9502181, Japan
[3] Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Aoba Ku, Sendai, Miyagi 9808577, Japan
来源：
SYNLETT | 2007年 / 08期
关键词：
catalysis; condensation; indoles; ionic liquids; supported catalysis;
D O I：
10.1055/s-2007-977453
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new organocatalytic procedure for the synthesis of bis(indolyl)methanes with acidic ionic liquid immobilized on silica gel (ILIS-SO2Cl) has been developed. The reaction condition is applicable to a variety of aryl and aliphatic aldehydes and indoles. The mild nature of the reaction conditions showed that the acetoxy or TBDMS group in the aldehyde was maintained intact. The catalyst was reused four times in 93% average yield.
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页码：1320 / 1322
页数：3
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