Effects of oolonghomobisflavan A on oxidation of low-density lipoprotein

被引：11

作者：

Sukhbold, Enkhtsetseg ^{[1
]}

Sekimoto, Shogo ^{[1
]}

Watanabe, Emiko ^{[1
]}

Yamazaki, Akane ^{[1
]}

Yang, Lifeng ^{[1
]}

Takasugi, Mikako ^{[2
]}

Yamada, Koji ^{[3
]}

Hosomi, Ryota ^{[4
]}

Fukunaga, Kenji ^{[4
]}

Arai, Hirofumi ^{[1
]}

机构：

[1] Kitami Inst Technol, Dept Biotechnol & Environm Chem, Kitami, Hokkaido, Japan

[2] Kyushu Sangyo Univ, Fac Engn, Fukuoka, Japan

[3] Sojo Univ, Fac Biotechnol & Life Sci, Kumamoto, Japan

[4] Kansai Univ, Fac Chem Mat & Bioengn, Suita, Osaka, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 08期

关键词：

oolong tea; polyphenols; antioxidant; low-density lipoprotein; oxidation; OOLONG TEA; MEDIATED OXIDATION; NITRIC-OXIDE; IN-VITRO; ATHEROSCLEROSIS; PEROXYNITRITE; POLYPHENOLS; HYDROPEROXIDES; PROTEINS; DYSLIPIDEMIA;

D O I：

10.1080/09168451.2017.1314758

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidation of low-density lipoprotein (LDL) by reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been suggested to be involved in the onset of atherosclerosis. Oolong tea contains unique polyphenols including oolonghomobisflavan A (OFA). In this study, the effects of OFA on LDL oxidation by ROS and RNS were investigated in vitro. OFA suppressed formation of cholesterol ester hydroperoxides in LDL oxidized by peroxyl radical and peroxynitrite, and formation of thiobarbituric acid reactive substances in LDL oxidized by Cu2+. In addition, OFA inhibited fragmentation, carbonylation, and nitration of apolipoprotein B-100 (apo B-100) in the oxidized LDL, in which heparin-binding activity of apo B-100 was protected by OFA. Our results suggest that OFA exhibits antioxidant activity against both lipid peroxidation and oxidative modification of apo B-100 in LDL oxidized by ROS and RNS. Polyphenols in oolong tea may prevent atherosclerosis by reducing oxidative stress.

引用

页码：1569 / 1575

页数：7

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