N-glycosylation profiling of Type 2 diabetes mellitus from baseline to follow-up: an observational study in a Ghanaian population

被引：8

作者：

Adua, Eric ^{[1
,2
,3
]}

Memarian, Elham ^{[4
]}

Afrifa-Yamoah, Ebenezer ^{[5
]}

Russell, Alyce ^{[1
]}

Trbojevic-Akmacic, Irena ^{[4
]}

Gudelj, Ivan ^{[4
]}

Juric, Julija ^{[4
]}

Roberts, Peter ^{[1
]}

Lauc, Gordan ^{[4
,6
]}

Wang, Wei ^{[1
,7
,8
]}

机构：

[1] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA 6027, Australia

[2] Edith Cowan Coll, Dept Hlth Sci, Bldg 80 Joondalup Campus West, Joondalup, WA, Australia

[3] Kwame Nkrumah Univ Sci & Technol, Dept Biochem & Biotechnol, Kumasi, Ghana

[4] Genos Glycosci Res Lab, Zagreb 10000, Croatia

[5] Edith Cowan Univ, Sch Sci, Joondalup, WA 6027, Australia

[6] Univ Zagreb, Fac Pharm & Biochem, Zagreb 10000, Croatia

[7] Taishan Med Univ, Sch Publ Hlth, Tai An 271000, Shandong, Peoples R China

[8] Capital Med Univ, Sch Publ Hlth, Beijing Key Lab Clin Epidemiol, Beijing 100069, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2021年 / 15卷 / 07期

关键词：

biomarker; N-glycans; stability; Type 2 diabetes mellitus; ultra-performance liquid chromatography; RECEPTOR SR-BI; RHEUMATOID-ARTHRITIS; IMMUNOGLOBULIN-G; GLYCAN PROFILES; IDENTIFICATION; BIOMARKERS; SERUM; ASSOCIATION; MECHANISMS; STABILITY;

D O I：

10.2217/bmm-2020-0615

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: The study sought to determine the patterns of N-glycan profiles among Type 2 diabetes mellitus (T2DM) patients over a 6-month period. Materials & methods: Biochemical and clinical data were obtained from 253 T2DM patients at baseline and follow-up. Ultra-performance liquid chromatography and statistical methods were applied for N-glycan profiling. Results: The coefficients of variation were 28% and 29% at baseline and follow-up, respectively, whereas the range of N-glycan variability was from 11% to 56%. Apart from GP1 (FA2) and GP29 (FA3G3S [3,3,3]3), the intra-individual variations of N-glycan peaks were not statistically significant. Conclusion: N-glycan profiles were stable over 6-month period in T2DM patients and could be used to monitor biochemical changes in relation with T2DM comorbidities.

引用

页码：467 / 480

页数：14

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