Unraveling the regulatory network in Streptococcus pyogenes:: the global response regulator CovR represses rivR directly

被引：30

作者：

Roberts, Samantha A. ^{[1
]}

Churchward, Gordon G. ^{[1
]}

Scott, June R. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

JOURNAL OF BACTERIOLOGY | 2007年 / 189卷 / 04期

关键词：

D O I：

10.1128/JB.01026-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The response regulator CovR acts as a master regulator of virulence in Streptococcus pyogenes by repressing transcription of approximately 15% of the group A streptococcus genome directly or indirectly. We demonstrate that phosphorylated CovR represses transcription of rivR directly by binding to conserved sequences located downstream from the promoter to block procession of RNA polymerase. This establishes the first link in a regulatory network where CovR interacts directly with other proteins that modulate gene expression.

引用

页码：1459 / 1463

页数：5

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