SIRT6 serves as a polyhedron in glycolytic metabolism and ageing-related diseases

被引：6
|
作者：
Yuan, Zhixiao [1 ]
Zeng, Yutian [1 ]
Tian, Yao [1 ]
Wang, Shuai [1 ]
Hong, Binyan [1 ]
Yang, Mingyao [1 ]
机构：
[1] Sichuan Agr Univ, Inst Anim Genet & Breeding, Chengdu 611130, Sichuan, Peoples R China
来源：
EXPERIMENTAL GERONTOLOGY | 2022年 / 162卷
关键词：
SIRT6; Cancer; Metabolism; Neurodegenerative diseases; Ageing; HISTONE DEACETYLASE SIRT6; EXTENDS LIFE-SPAN; TELOMERE MAINTENANCE; CARDIAC-HYPERTROPHY; TUMOR-SUPPRESSOR; CANCER-CELLS; STEM-CELLS; DNA-REPAIR; EXPRESSION; ACTIVATION;
D O I：
10.1016/j.exger.2022.111765
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD(+))-dependent enzyme. It is a novel member of the sirtuin family that has been shown to have an important role in various molecular pathways in glycolysis, cancer, and neurodegenerative responses. Recently, SIRT6 has emerged as a prominent research issue because its biochemical activity and regulation are possibly associated with human metabolism and disease. In this review, we summarized the connection between SIRT6 and glycolytic metabolism; discussed recent developments in the involvement of SIRT6 in a variety of life-threatening illnesses, including cancer, neurodegenerative diseases and cardiovascular disease; and explored possible treatment approaches for those diseases with SIRT6. This review provides insights into the role of SIRT6 in disease.
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页数：9
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