Cortisol trajectory, melancholia, and response to electroconvulsive therapy
被引:12
|
作者:
Mickey, Brian J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USAUniv Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
Mickey, Brian J.
[1
,2
]
论文数: 引用数:
h-index:
机构:
Ginsburg, Yarden
[2
]
Sitzmann, Adam F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USAUniv Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
Sitzmann, Adam F.
[2
]
Grayhack, Clara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USAUniv Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
Grayhack, Clara
[2
]
Sen, Srijan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USAUniv Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
Sen, Srijan
[2
]
Kirschbaum, Clemens
论文数: 0引用数: 0
h-index: 0
机构:
Tech Univ Dresden, Dept Psychol, Dresden, GermanyUniv Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
Kirschbaum, Clemens
[3
]
Maixner, Daniel F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USAUniv Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
Maixner, Daniel F.
[2
]
Abelson, James L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USAUniv Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
Abelson, James L.
[2
]
机构:
[1] Univ Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
[2] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USA
While biomarkers have been used to define pathophysiological types and to optimize treatment in many areas of medicine, in psychiatry such biomarkers remain elusive. Based on previously described abnormalities of hypothalamic -pituitary-adrenal (HPA) axis function in severe forms of depression, we hypothesized that the temporal trajectory of basal cortisol levels would vary among individuals with depression due to heterogeneity in pathophysiology, and that cortisol trajectories that reflect elevated or increasing HPA activity would predict better response to electroconvulsive therapy (ECT). To test that hypothesis, we sampled scalp hair from 39 subjects with treatment-resistant depression just before ECT. Cortisol trajectory over the 12 weeks preceding ECT was reconstructed from cortisol concentrations in sequential hair segments. Cortisol trajectories varied widely between individuals, and exploratory analyses of clinical features revealed associations with melancholia and global severity. ECT non-responders showed a decreasing trajectory (mean change 25%, 95% CI = [-1%,-43%]) during the 8 weeks preceding ECT (group-by-time interaction, p = 0.004). The association between cortisol trajectory and subsequent ECT response was independent of clinical features. A classification algorithm showed that cortisol trajectory predicted ECT response with 80% accuracy, suggesting that this biomarker might be developed into a clinically useful test for ECT-responsive depression. In conclusion, cortisol trajectory mapped onto symptoms of melancholia and independently predicted response to ECT in this severely depressed sample. These findings deserve to be replicated in a larger sample. Cortisol trajectory holds promise as a reliable, noninvasive, inexpensive biomarker for psychiatric disorders.
机构:
Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USAHarvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
Andreou, Blake
Reid, Benjamin
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USAHarvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
Reid, Benjamin
Lyall, Amanda E.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USAHarvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
Lyall, Amanda E.
Cetin-Karayumak, Suheyla
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USAHarvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
Cetin-Karayumak, Suheyla
Kubicki, Antoni
论文数: 0引用数: 0
h-index: 0
机构:
David Geffen Sch Med, Ahmanson Lovelace Brain Mapping Ctr, Dept Neurol, Los Angeles, CA USAHarvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
Kubicki, Antoni
Espinoza, Randall
论文数: 0引用数: 0
h-index: 0
机构:
David Geffen Sch Med, Jane & Terry Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA USAHarvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
Espinoza, Randall
论文数: 引用数:
h-index:
机构:
Kruse, Jennifer
Narr, Katherine L.
论文数: 0引用数: 0
h-index: 0
机构:
David Geffen Sch Med, Jane & Terry Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA
Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USAHarvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
Narr, Katherine L.
Kubicki, Marek
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA
Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USAHarvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
机构:
Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Ji, Yang
Huang, Wanling
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Huang, Wanling
Zheng, Shuang
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Mental Hlth Ctr, Hefei 230022, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Zheng, Shuang
Zheng, Hao
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Zheng, Hao
Qian, Rui
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Qian, Rui
Duan, Nanxue
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Duan, Nanxue
Li, Wenfei
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Mental Hlth Ctr, Hefei 230022, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Li, Wenfei
Wang, Long
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Mental Hlth Ctr, Hefei 230022, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Wang, Long
Wu, Xingqi
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Wu, Xingqi
Wang, Kai
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Anhui Prov Key Lab Cognit & Neuropsychiat Disorder, Hefei 230032, Peoples R China
Anhui Med Univ, Coll Mental Hlth & Psychol Sci, Hefei 230032, Peoples R China
Collaborat Innovat Ctr Neuropsychiat Disorders & M, Hefei 230032, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Wang, Kai
Tian, Yanghua
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
Anhui Mental Hlth Ctr, Hefei 230022, Peoples R China
Anhui Med Univ, Coll Mental Hlth & Psychol Sci, Hefei 230032, Peoples R China
Collaborat Innovat Ctr Neuropsychiat Disorders & M, Hefei 230032, Peoples R ChinaAnhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China