Microwave enabled external carboxymethyl substituents in the ring-closing metathesis

被引：77
|
作者：
Yang, CM [1 ]
Murray, WV [1 ]
Wilson, LJ [1 ]
机构：
[1] Johnson & Johnson Pharmaceut & Dev LLC, Raritan, NJ 08869 USA
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 09期
关键词：
D O I：
10.1016/S0040-4039(03)00083-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The ring-closing metathesis of diolefin substrates containing an external carboxymethyl substituent is presented. The reaction is enabled through microwave irradiation allowing greatly enhanced yields and conversion rates. The reaction results in the formation of carboxymethyl substituted dihydropyrroles, dihydrofurans, and cyclopentenes. In certain cases, pyrroles are formed through further in situ oxidation. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1783 / 1786
页数：4
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