Assessment of metabolic viability of cryopreserved hepatocytes and liver microsomes using bufuralol as a model substrate

被引:0
|
作者
Padrós, J [1 ]
Tran, PQ [1 ]
Daly, E [1 ]
Chun, D [1 ]
Flarakos, T [1 ]
机构
[1] MDS Pharma Serv, Montreal, PQ H4R 2N6, Canada
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
420
引用
收藏
页码:210 / 210
页数:1
相关论文
共 50 条
  • [31] Effects of indoxylsulfate on the in vitro hepatic metabolism of various compounds using human liver microsomes and hepatocytes
    Hanada, Kazuhiko
    Ogawa, Rie
    Son, Kishin
    Sasaki, Yuuki
    Kikkawa, Akashi
    Ichihara, Shiho
    Ogata, Hiroyasu
    NEPHRON PHYSIOLOGY, 2006, 103 (04): : 179 - 186
  • [32] Characterization of a metabolic interference between rilpivirine and budesonide using human liver microsomes
    Feisthauer, Emilie
    Ameline, Alice
    Gheddar, Laurie
    Raul, Jean-Sebastien
    Kintz, Pascal
    TOXICOLOGIE ANALYTIQUE ET CLINIQUE, 2020, 32 (02) : 106 - 110
  • [33] Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes
    Jones, HM
    Hallifax, D
    Houston, JB
    DRUG METABOLISM AND DISPOSITION, 2004, 32 (05) : 572 - 580
  • [34] Characterization of the in Vitro Metabolic Profile of Evodiamine in Human Liver Microsomes and Hepatocytes by UHPLC-Q Exactive Mass Spectrometer
    Zhang, Zhaowei
    Fang, Tianzi
    Zhou, Hongyun
    Yuan, Jie
    Liu, Qingwang
    FRONTIERS IN PHARMACOLOGY, 2018, 9
  • [35] Assessment of cryopreserved human hepatocytes as a model system to investigate sulfation and glucuronidation and to evaluate inhibitors of drug conjugation
    Riches, Z.
    Bloomer, J.
    Patel, A.
    Nolan, A.
    Coughtrie, M.
    XENOBIOTICA, 2009, 39 (05) : 374 - 381
  • [36] Do cryopreserved sandwich cultured human hepatocytes better predict in-vivo CYP3A inactivation DDIs than human liver microsomes?
    Kirby, Brian J.
    Grepper, Susan
    Unadkat, Jashvant D.
    DRUG METABOLISM REVIEWS, 2011, 43 : 32 - 32
  • [37] RESCUE OF A METABOLIC LIVER DISEASE MODEL BY GENETICALLY ENGINEERED HYPOIMMUNOGENIC HUMAN HEPATOCYTES
    Vo, Karen
    Kim, Junmo
    Meckiff, Benjamin J.
    Sanghvi, Kanchi
    Juang, Charity
    Mikesell, Glen
    Geng, Tao
    Stewart, Leslie
    Lopez, Sandy E.
    Orrego, Esequiel
    Hulse, Jason
    Shabbir, Ayesha
    Stumpf, Kaitlin
    Witek, Rafal P.
    Peixoto, Gabriel
    Mendoza, Alan
    Wilson, Elizabeth M.
    Mao, Tin
    Hollenbach, Stanley J.
    Grompe, Markus
    Holmes, Michael C.
    Hickey, Raymond Daniel
    Yi, Fei
    HEPATOLOGY, 2022, 76 : S463 - S464
  • [38] Assessment of In Silico and In Vitro Selpercatinib Metabolic Stability in Human Liver Microsomes Using a Validated LC-MS/MS Method
    Attwa, Mohamed W.
    AlRabiah, Haitham
    Mostafa, Gamal A. E.
    Bakheit, Ahmed H.
    Kadi, Adnan A.
    MOLECULES, 2023, 28 (06):
  • [39] A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes
    Riley, RJ
    McGinnity, DF
    Austin, RP
    DRUG METABOLISM AND DISPOSITION, 2005, 33 (09) : 1304 - 1311
  • [40] Assessment of Compound Hepatotoxicity Using Human Plateable Cryopreserved Hepatocytes in a 1536-Well-Plate Format
    Moeller, Timothy A.
    Shukla, Sunita J.
    Xia, Menghang
    ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2012, 10 (01) : 78 - 87