Serotype distribution and antimicrobial susceptibility of S. pneumoniae causing invasive disease in Thai children younger than 5 years old, 2000-2005

被引：34

作者：

Phongsamart, Wanatpreeya ^{[1
]}

Srifeungfung, Somporn ^{[1
]}

Dejsirilert, Surang ^{[1
]}

Chatsuwan, Tanittha ^{[1
]}

Nunthapisud, Pongpun ^{[1
]}

Treerauthaweeraphong, Vipa ^{[1
]}

Rungnobhakhun, Pimpha ^{[1
]}

Chokephailbulkit, Kulkanya ^{[1
]}

机构：

[1] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Pediat,Div Infect Dis, Bangkok 10700, Thailand

来源：

VACCINE | 2007年 / 25卷 / 07期

关键词：

Streptococcus pneumoniae; serotypes; pneumococcal conjugate vaccine; Thai children; antimicrobial susceptibility;

D O I：

10.1016/j.vaccine.2006.10.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to predict the potential benefit of pneumococcal conjugate vaccines (PCV), we evaluated the serotype coverage of the 7-, 9-, 11- and 13-vatent PCV over the isolates causing invasive pneumococcal disease (IPD) in Thai children. One hundred and fifteen Streptococcus pneumoniae isolates from sterile sites in children younger than 5 years old between 2000 and 2005 were serotyped. The coverages of 7-, 9-, 11-, and 13-valent PCV were 69%, 73.8%, 73.8% and 85.7% in children younger than 2 years, and 73.9%, 77.4%. 77.4% and 87.8% in children younger than 5 years of age, respectively. 69.6% and 22.6% of the isolates were non-susceptible to penicillin and cefotaxime. 7-valent PCV covered 89% and 100% of penicillin and cefotaxime non-susceptible isolates. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1275 / 1280

页数：6