Both self and non-inherited maternal HLA antigens influence the immune response

被引：49
|
作者：
van Rood, JJ [1 ]
Claas, F [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2300 RC Leiden, Netherlands
来源：
IMMUNOLOGY TODAY | 2000年 / 21卷 / 06期
关键词：
D O I：
10.1016/S0167-5699(00)01628-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent studies suggest that exposure of the fetus and newborn to non-inherited maternal major histocompatibility complex HLA antigens (NIMA) has a life-long effect on allograft recognition that could influence tolerance of organ grafts. NIMA also appear to influence disease susceptibility. Here, Jon van Rood and Frans Claas discuss evidence that three HLA haplotypes, those inherited from the parents plus NIMA, shape the immune response.
引用
收藏
页码：269 / 273
页数：5
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