The membrane complement regulatory protein CD59 promotes tumor growth and predicts poor prognosis in breast cancer

被引：30

作者：

Ouyang, Qianwen ^{[1
,2
,3
,4
,5
]}

Zhang, Long ^{[3
,4
,6
]}

Jiang, Yizhou ^{[2
,3
,4
]}

Ni, Xiaojian ^{[2
,3
,4
]}

Chen, Sheng ^{[2
,3
,4
]}

Ye, Fugui ^{[7
]}

Du, Yiqun ^{[4
,8
]}

Huang, Liang ^{[2
,3
,4
]}

Ding, Peipei ^{[3
,4
,6
]}

Wang, Na ^{[3
]}

Yang, Chaoqun ^{[9
]}

Huang, Tianbao ^{[10
]}

Sun, Yujing ^{[3
]}

Li, Shan ^{[2
,3
,4
]}

Xia, Yun ^{[1
]}

Hu, Weiguo ^{[3
,4
,6
]}

Luo, Rongcheng ^{[2
,5
]}

Shao, Zhiming ^{[3
,4
,6
]}

机构：

[1] Third Hosp Nanchang, China Jiangxi Prov Key Lab Breast Dis, Dept Breast Surg, Nanchang, Jiangxi, Peoples R China

[2] Fudan Univ, Key Lab Breast Canc Shanghai, Dept Breast Surg, Shanghai 200032, Peoples R China

[3] Fudan Univ, Inst Canc, Shanghai Canc Ctr, Shanghai 200032, Peoples R China

[4] Fudan Univ, Dept Oncol, Shanghai Med Coll, Shanghai 200032, Peoples R China

[5] Southern Med Univ, Ctr Canc, Tradit Chinese Med Integrated Hosp, 1838 Guangzhou N Ave, Guangzhou 510515, Guangdong, Peoples R China

[6] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

[7] Fujian Med Univ, Union Clin Sch, Affiliated Union Hosp, Dept Gen Surg, Fuzhou, Fujian, Peoples R China

[8] Fudan Univ, Huashan Hosp, Dept Med Oncol, Shanghai Canc Ctr, Shanghai 200032, Peoples R China

[9] Fudan Univ, Huashan Hosp, Dept Hand Surg, Shanghai 200032, Peoples R China

[10] Tongji Univ, Shanghai Peoples Hosp 10, Dept Urol, Shanghai 200092, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2016年 / 48卷 / 05期

基金：

中国国家自然科学基金;

关键词：

MDA-MB-231-HM; CD59; tumor growth; breast cancer; poor prognosis; ESTROGEN-RECEPTOR; BINDING PROTEIN; EXPRESSION; IMMUNOTHERAPY; TRASTUZUMAB; APOPTOSIS; TARGET; CELLS; GENE; CREB;

D O I：

10.3892/ijo.2016.3408

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is the most prevalent type of cancer among women. CD59, a membrane complement regulatory protein, has been demonstrated to be overexpressed in most solid tumors, where it facilitates tumor cell escape from complement surveillance. However, the role of CD59 in breast cancer growth and clinical prognosis is not fully revealed. To investigate the role of CD59 in breast cancer growth and prognostic significance, we knocked down CD59 in a breast cancer cell line that is highly metastatic to the lungs, MDA-MB-231-HM. Cell growth was measured in vitro and in vivo using a xenograft model. In addition, clinical data on a cohort of 120 patients with or without lung metastasis was analyzed based on CD59 expression, which was detected by immunohistochemistry. Knockdown of CD59 significantly inhibited MDA-MB-231-HM cell growth both in vitro and in vivo. An analysis of clinical data on 120 patients revealed that patients with CD59 overexpression may have a worse prognosis. CD59 may therefore be a prognostic biomarker for poor outcome in breast cancer patients.

引用

页码：2015 / 2024

页数：10

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