Metabolic Vulnerabilities in Brain Cancer

被引：4
|
作者：
Morrow, Danielle [1 ,3 ]
Minami, Jenna [1 ,3 ]
Nathanson, David A. [1 ,2 ,3 ]
机构：
[1] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90024 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[3] UCLA CHS 23-234,650 Charles E Young Dr South, Los Angeles, CA 90036 USA
来源：
NEUROSURGERY CLINICS OF NORTH AMERICA | 2021年 / 32卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Metabolism; GBM; Tumor microenvironment; Oncogene; CHOLESTEROL-METABOLISM; CELLULAR-METABOLISM; HUMAN GLIOBLASTOMAS; CO-DEPENDENCY; IDH-MUTANT; CELLS; TUMORS; LANDSCAPE; OXIDATION; GROWTH;
D O I：
10.1016/j.nec.2020.12.006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Glioblastomas (GBMs) exhibit altered metabolism to support a variety of bioenergetic and biosynthetic demands for tumor growth, invasion, and drug resistance. Changes in glycolytic flux, oxidative phosphorylation, the pentose phosphate pathway, fatty acid biosynthesis and oxidation, and nucleic acid biosynthesis are observed in GBMs to help drive tumorigenesis. Both the genetic landscape of GBMs and the unique brain tumor microenvironment shape metabolism; therefore, an understanding of how both intrinsic and extrinsic factors modulate metabolism is becoming increasingly important for finding effect targets and therapeutics for GBM. © 2021 Elsevier Inc.
引用
收藏
页码：159 / 169
页数：11
相关论文
共 50 条
  • [21] Exploring metabolic vulnerabilities of metastatic prostate cancer to bone
    Mossa, Federica
    Robesti, Daniele
    Vellano, Christopher
    Titus, Mark
    Marszalek, Joe
    Frigo, Daniel
    Logothetis, Christopher
    Gujral, Taranjit
    Dondossola, Eleonora
    CANCER RESEARCH, 2023, 83 (07)
  • [22] Oncogenic KRAS Drives Metabolic Vulnerabilities by Directly Regulating Metabolic Enzymes in Cancer
    Zhang, Liyi
    GLOBAL MEDICAL GENETICS, 2020, 7 (01): : 1 - 2
  • [23] Metabolic drug survey highlights cancer cell dependencies and vulnerabilities
    Tea Pemovska
    Johannes W. Bigenzahn
    Ismet Srndic
    Alexander Lercher
    Andreas Bergthaler
    Adrián César-Razquin
    Felix Kartnig
    Christoph Kornauth
    Peter Valent
    Philipp B. Staber
    Giulio Superti-Furga
    Nature Communications, 12
  • [24] Targeting metabolic vulnerabilities of cancer: Small molecule inhibitors in clinic
    Tripathi, Satyendra C.
    Fahrmann, Johannes F.
    Vykoukal, Jody V.
    Dennison, Jennifer B.
    Hanash, Samir M.
    CANCER REPORTS, 2019, 2 (01)
  • [25] Metabolic Drug Survey Highlights Cancer Cell Dependencies and Vulnerabilities
    Pemovska, Tea
    Bigenzahn, Johannes
    Srndic, Ismet
    Lercher, Alexander
    Bergthaler, Andreas
    Razquin, Adrian Cesar
    Kartnig, Felix
    Staber, Philipp B.
    Furga, Giulio Superti
    BLOOD, 2020, 136
  • [26] Cardio-Onco-Metabolism - Metabolic vulnerabilities in cancer and the heart
    Karlstaedt, Anja
    Taegtmeyer, Heinrich
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022, 171 : 71 - 80
  • [27] Metabolic drug survey highlights cancer cell dependencies and vulnerabilities
    Pemovska, Tea
    Bigenzahn, Johannes
    Srndic, Ismet
    Lercher, Alexander
    Bergthaler, Andreas
    Cesar-Razquin, Adrian
    Kartnig, Felix
    Kornauth, Christoph
    Valent, Peter
    Staber, Philipp B.
    Superti-Furga, Giulio
    NATURE COMMUNICATIONS, 2021, 12 (01)
  • [28] Exploiting metabolic vulnerabilities of ovarian cancer with upregulated succinate dehydrogenase
    Wang, Lin
    Bulicz, Magdalena
    Mucha, Patryk
    Kinter, Michael
    Pranay, Atul
    Griffin, Timothy M.
    Miller, Benjamin F.
    Bieniasz, Magdalena
    CANCER RESEARCH, 2023, 83 (07)
  • [29] Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities
    Lanning, Nathan J.
    Castle, Joshua P.
    Singh, Simar J.
    Leon, Andre N.
    Tovar, Elizabeth A.
    Sanghera, Amandeep
    MacKeigan, Jeffrey P.
    Filipp, Fabian V.
    Graveel, Carrie R.
    CANCER & METABOLISM, 2017, 5
  • [30] Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities
    Nathan J. Lanning
    Joshua P. Castle
    Simar J. Singh
    Andre N. Leon
    Elizabeth A. Tovar
    Amandeep Sanghera
    Jeffrey P. MacKeigan
    Fabian V. Filipp
    Carrie R. Graveel
    Cancer & Metabolism, 5
12345