A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy

被引：22
|
作者：
Yan, Yongchao [1 ,2 ]
Fu, Hao [3 ]
Wang, Jian [1 ,2 ]
Chen, Chuanrong [3 ]
Wang, Qi [1 ,2 ]
Duan, Yourong [3 ]
Hua, Jianli [1 ,2 ]
机构：
[1] East China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, 130 Meilong Rd, Shanghai 200237, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Biomed Engn, Reiji Hosp, State Key Lab Oncogenes & Related Genes, 25 Xietu Rd, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 73期
基金：
中国国家自然科学基金;
关键词：
IN-VIVO; NANOPARTICLES; CYTOTOXICITY; THERANOSTICS;
D O I：
10.1039/c9cc05624f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Different from traditional "always on" photothermal therapy (PTT) agents, tumor microenvironment responsive agents showed more tumor specificity and lower photo-toxicity to normal tissues. Herein, a photo-stable and reversible pH responsive phenazine dye (PIOH) was synthesized and assembled with liposomes forming nanoparticles (PIOH-NPs), which exhibited a strong NIR absorption in a weak acid environment and were successfully utilized for photoacoustic (PA) imaging-guided photothermal therapy in mice.
引用
收藏
页码：10940 / 10943
页数：4
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