A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy

被引：22
|
作者：
Yan, Yongchao [1 ,2 ]
Fu, Hao [3 ]
Wang, Jian [1 ,2 ]
Chen, Chuanrong [3 ]
Wang, Qi [1 ,2 ]
Duan, Yourong [3 ]
Hua, Jianli [1 ,2 ]
机构：
[1] East China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, 130 Meilong Rd, Shanghai 200237, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Biomed Engn, Reiji Hosp, State Key Lab Oncogenes & Related Genes, 25 Xietu Rd, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 73期
基金：
中国国家自然科学基金;
关键词：
IN-VIVO; NANOPARTICLES; CYTOTOXICITY; THERANOSTICS;
D O I：
10.1039/c9cc05624f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Different from traditional "always on" photothermal therapy (PTT) agents, tumor microenvironment responsive agents showed more tumor specificity and lower photo-toxicity to normal tissues. Herein, a photo-stable and reversible pH responsive phenazine dye (PIOH) was synthesized and assembled with liposomes forming nanoparticles (PIOH-NPs), which exhibited a strong NIR absorption in a weak acid environment and were successfully utilized for photoacoustic (PA) imaging-guided photothermal therapy in mice.
引用
收藏
页码：10940 / 10943
页数：4
相关论文
共 32 条
  • [1] NIR organic dyes based on phenazine-cyanine for photoacoustic imaging-guided photothermal therapy
    Yan Y.
    Chen J.
    Yang Z.
    Zhang X.
    Liu Z.
    Hua J.
    Liu, Zhuang (zliu@suda.edu.cn), 2018, Royal Society of Chemistry (06) : 7420 - 7426
  • [2] NIR organic dyes based on phenazine-cyanine for photoacoustic imaging-guided photothermal therapy
    Yan, Yongchao
    Chen, Jiawen
    Yang, Zhijuan
    Zhang, Xiao
    Liu, Zhuang
    Hua, Jianli
    JOURNAL OF MATERIALS CHEMISTRY B, 2018, 6 (45) : 7420 - 7426
  • [3] Tantalum Nitride-Based Theranostic Agent for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR Window
    Yi, Huixi
    Yan, Gaoyang
    He, Jinzhen
    Zhuang, Jiani
    Jin, Chengzhi
    Zhang, Dong-Yang
    NANOMATERIALS, 2023, 13 (11)
  • [4] Albumin-NIR dye self-assembled nanoparticles for photoacoustic pH imaging and pH-responsive photothermal therapy effective for large tumors
    Chen, Qian
    Liu, Xiaodong
    Zeng, Jianfeng
    Cheng, Zhenping
    Liu, Zhuang
    BIOMATERIALS, 2016, 98 : 23 - 30
  • [5] NIR imaging-guided combined photodynamic therapy and chemotherapy by a pH-responsive amphiphilic polypeptide prodrug
    Ruan, Zheng
    Liu, Le
    Jiang, Wei
    Li, Shuya
    Wang, Yucai
    Yan, Lifeng
    BIOMATERIALS SCIENCE, 2017, 5 (02) : 313 - 321
  • [6] Highly photostable croconium dye-anchored cell membrane vesicle for tumor pH-responsive duplex imaging-guided photothermal therapy
    Gao, Xiaoting
    Jiang, Shanshan
    Li, Chunying
    Chen, Yunzhi
    Zhang, Yifan
    Huang, Peng
    Lin, Jing
    BIOMATERIALS, 2021, 267
  • [7] Facile Synthesis of Melanin-Dye Nanoagent for NIR-II Fluorescence/Photoacoustic Imaging-Guided Photothermal Therapy
    Sun, Jinghua
    Cai, Wenwen
    Sun, Yao
    Guo, Chunyan
    Zhang, Ruiping
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 15 : 10199 - 10213
  • [8] pH-Responsive Fe(III)-Gallic Acid Nanoparticles for In Vivo Photoacoustic-Imaging-Guided Photothermal Therapy
    Zeng, Jianfeng
    Cheng, Ming
    Wang, Yong
    Wen, Ling
    Chen, Ling
    Li, Zhen
    Wu, Yongyou
    Gao, Mingyuan
    Chai, Zhifang
    ADVANCED HEALTHCARE MATERIALS, 2016, 5 (07) : 772 - 780
  • [9] pH-responsive Ag2S nanodots loaded with heat shock protein 70 inhibitor for photoacoustic imaging-guided photothermal cancer therapy
    Zhong, Yaping
    Zou, Yibiao
    Liu, Lingyan
    Li, Ruohan
    Xue, Fengfeng
    Yi, Tao
    ACTA BIOMATERIALIA, 2020, 115 : 358 - 370
  • [10] Engineering of an endogenous hydrogen sulfide responsive smart agent for photoacoustic imaging-guided combination of photothermal therapy and chemotherapy for colon cancer
    Tian, Qiwei
    Wang, Xiaodong
    Song, Shaoli
    An, Lu
    Yang, Shiping
    Huang, Gang
    JOURNAL OF ADVANCED RESEARCH, 2022, 41 : 159 - 168
1234