An insertion/deletion in the porcine FGFR2 gene

被引:3
|
作者
Aldenhoven, J.
Spoetter, A.
Distl, O.
机构
[1] Univ Vet Med, Inst Anim Breeding & Genet, D-30559 Hannover, Germany
[2] Univ Sydney, Fac Vet Sci, Ctr Adv Technol Anim Genet & Reprod Reprogen, Sydney, NSW 2006, Australia
关键词
fibroblast growth factor; gene mapping; pig;
D O I
10.1111/j.1439-0388.2007.00629.x
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
The 7000-rad INRA-University of Minnesota porcine Radiation Hybrid panel was used to localize the FGFR2 gene on Sus scrofa chromosome 14 (SSC14). An insertion/deletion mutation of approximately 240 bp was detected in the porcine FGFR2 gene. This mutation consists of a repeat motif of 48 bp. In a short and long variant of this polymorphism, the motif was repeated either six or 11 times. The mutation was shown to follow a Mendelian mode of inheritance in 10 families including 48 pigs of Large White x Duroc origin.
引用
收藏
页码:39 / 41
页数:3
相关论文
共 50 条
  • [31] Incidence of FGFR2 Amplification and FGFR2 Fusion in Patients with Metastatic Cancer Using Clinical Sequencing
    Hyung, Sujin
    Han, Boram
    Jung, Jaeyun
    Kim, Seung Tae
    Hong, Jung Yong
    Park, Se Hoon
    Zang, Dae Young
    Park, Joon Oh
    Park, Young Suk
    Kim, Kyoung-Mee
    Kang, Won Ki
    Lee, Jeeyun
    JOURNAL OF ONCOLOGY, 2022, 2022
  • [32] Constitutive receptor activation by Crouzon syndrome mutations in FGFR2 and FGFR2/Neu chimeras.
    Donoghue, DJ
    Galvin, BD
    Hart, KC
    Meyer, AN
    Webster, MK
    MOLECULAR BIOLOGY OF THE CELL, 1996, 7 : 1090 - 1090
  • [33] Genomic organization of the human fibroblast growth factor receptor 2 (FGFR2) gene and comparative analysis of the human FGFR gene family
    Zhang, YZ
    Gorry, MC
    Post, JC
    Ehrlich, GD
    GENE, 1999, 230 (01) : 69 - 79
  • [34] BCL2 enhances survival of porcine pluripotent stem cells through promoting FGFR2
    Zhu, Zhenshuo
    Pan, Qin
    Zhao, Wenxu
    Wu, Xiaolong
    Yu, Shuai
    Shen, Qiaoyan
    Zhang, Juqing
    Yue, Wei
    Peng, Sha
    Li, Na
    Zhang, Shiqiang
    Lei, Anmin
    Hua, Jinlian
    CELL PROLIFERATION, 2021, 54 (01)
  • [35] FGFR2 signaling and the pathogenesis of acne
    Melnik, Bodo
    Schmitz, Gerd
    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2008, 6 (09): : 721 - 728
  • [36] FGFR2 alterations in endometrial carcinoma
    Gatius, Sonia
    Velasco, Ana
    Azueta, Ainara
    Santacana, Maria
    Pallares, Judit
    Valls, Joan
    Dolcet, Xavier
    Prat, Jaime
    Matias-Guiu, Xavier
    MODERN PATHOLOGY, 2011, 24 (11) : 1500 - 1510
  • [37] Fetal microtia and FGFR2 polymorphism
    Zhao, Ruilian
    Du, Peixia
    Sun, Hongmei
    Yang, Li
    Lin, Pingzhen
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 18 (01) : 384 - 388
  • [38] A de novo Alu element insertion into an intron of FGFR2 causes Apert syndrome.
    Oldridge, M
    McDonald-McGinn, DM
    Zackal, EH
    Wilkie, AOM
    AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (04) : A342 - A342
  • [39] Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma
    Goyal, Lipika
    Saha, Supriya K.
    Liu, Leah Y.
    Siravegna, Giulia
    Leshchiner, Ignaty
    Ahronian, Leanne G.
    Lennerz, Jochen K.
    Vu, Phuong
    Deshpande, Vikram
    Kambadakone, Avinash
    Mussolin, Benedetta
    Reyes, Stephanie
    Henderson, Laura
    Sun, Jiaoyuan Elisabeth
    Van Seventer, Emily E.
    Gurski, Joseph M., Jr.
    Baltschukat, Sabrina
    Schacher-Engstler, Barbara
    Barys, Louise
    Stamm, Christelle
    Furet, Pascal
    Ryan, David P.
    Stone, James R.
    Iafrate, A. John
    Getz, Gad
    Porta, Diana Graus
    Tiedt, Ralph
    Bardelli, Alberto
    Juric, Dejan
    Corcoran, Ryan B.
    Bardeesy, Nabeel
    Zhu, Andrew X.
    CANCER DISCOVERY, 2017, 7 (03) : 252 - 263
  • [40] FGFR1 and FGFR2 Mutations in Pfeiffer Syndrome
    Chokdeemboon, Chayanin
    Mahatumarat, Charan
    Rojvachiranonda, Nond
    Tongkobpetch, Siraprapa
    Suphapeetiporn, Kanya
    Shotelersuk, Vorasuk
    JOURNAL OF CRANIOFACIAL SURGERY, 2013, 24 (01) : 150 - 152