Stereoselective synthesis of substituted pyrrolidines by a domino Michael addition/carbocyclization reaction

被引：0
|
作者：
Denes, F [1 ]
Chemla, F [1 ]
Normant, JF [1 ]
机构：
[1] Univ Paris 06, Chim Organ Lab, UMR 7611, F-75252 Paris 05, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 2002卷 / 21期
关键词：
Michael addition; cyclization; copper; zinc; domino reactions; nitrogen heterocycles;
D O I：
10.1002/1099-0690(200211)2002:21<3536::AID-EJOC3536>3.0.CO;2-L
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The domino 1,4-addition/carbocyclization/functionalization reaction of Michael acceptor 3 with mixed copper/zinc reagents allows the totally diastereoselective formation of 3,4-disubstituted-3-carbomethoxypyrrolidines in a three-component one-pot sequence. ((C) Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).
引用
收藏
页码：3536 / 3542
页数：7
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