Long Chain Effects on DNA-Binding and Cytotoxicity to Cancer Cells in Metallo-Supramolecular Oligomers

被引：1
|
作者：
Rana, Utpal [1 ]
Hossain, Md. Delwar [1 ,3 ]
Chakraborty, Chanchal [1 ,2 ]
Nagano, Reiko [4 ]
Morita, Hiromi [4 ]
Hattori, Shinya [4 ]
Minowa, Takashi [4 ]
Higuchi, Masayoshi [1 ]
机构：
[1] NIMS, Elect Funct Macromol Grp, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan
[2] Birla Inst Technol & Sci, Dept Chem, Hyderabad Campus, Secunderabad 500078, Telangana, India
[3] Jagannath Univ, Dept Chem, Fac Sci, Dhaka 1100, Bangladesh
[4] NIMS, Nanotechnol Innovat Stn, 1-2-1 Sengen, Tsukuba, Ibaraki 3050047, Japan
来源：
CHEMISTRYSELECT | 2018年 / 3卷 / 26期
关键词：
apoptosis; cytotoxicity; DNA binding; DNA recognition; metallo-supramolecular oligomer; LIGHT-SWITCH; IN-VITRO; COMPLEXES; RUTHENIUM(II); INTERCALATION; ANTITUMOR;
D O I：
10.1002/slct.201800961
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We synthesized Fe(II)-based metallo-supramolecular oligomers with the different degree of polymerization (DP) (DP-1, -5 and -10) by changing the molar ratio of Fe(II) acetate and bis (terpyridyl)benzene to 1:2, 5:6, and 10:11, respectively. We investigated the chain length effects on the binding affinity to DNA and cytotoxicity to cancer cells in the oligomers. DP-10 showed five-time larger DNA binding constant and four-time stronger cytotoxicity than DP-1. We also studied the cell apoptosis assay using annexin V-FITC/PI staining by flow cytometry and revealed that the ratio of early and late apoptosis cells increased from 15.6% (DP-1) to 61.4% (DP-10) with increasing the chain length.
引用
收藏
页码：7586 / 7591
页数：6
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