Study on the Influence of Free Radicals and Oxidative Stress on Peptic Ulcers

被引：0

作者：

Balint, Germaine Savoiu ^{[1
]}

Toth, Emeric ^{[2
]}

Andoni, Mihaiela ^{[1
]}

Demeter, Ioan ^{[2
]}

Borza, Claudia ^{[2
]}

Floroni, Erwin ^{[2
]}

Pacurar, Mariana ^{[3
]}

Ciobanu, Virgil ^{[2
]}

机构：

[1] Univ Med & Pharm Victor Babes Timisoara, Fac Pharm, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

[2] Univ Med & Pharm Victor Babes Timi Oara, Fac Med, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

[3] Univ Med & Pharm Targu Mures, Fac Dent, 38 Gh Marinescu Str, Targu Mures 540072, Romania

来源：

REVISTA DE CHIMIE | 2019年 / 70卷 / 09期

关键词：

oxidative stress; gastric ulcer; reactive oxygen species; reactive nitrogen species; MERCURY; CHOLESTEROL;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It can be observed that oxidative stress initiates and aggravates many diseases, including peptic ulcers and gastric carcinoma. An increase in rat mucosal glandular lipid peroxidation (LPO) and superoxide dismutase (SOD) and a decrease in catalase (CAT) levels in gastric ulceration induced by cold retention stress were observed, whereas in patients with ulcerated clinical peptic and gastric carcinoma LPO serum is associated with a decrease in SOD and CAT. It was intended to determine the parameters of oxidative stress in the blood and brain in rats after induction of gastric ulcer, the effect of antioxidant treatment on these parameters and on the appearance of gastric ulcer, determination of correlation between oxidative stress and severity of gastric ulcer in rats and also evaluation of vascular endothelial function by in vitro studies in the organ bath, from rat aortic rings with gastric ulcer vs. normal and others under treatment vs. untreated.

引用

页码：3254 / 3257

页数：4

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