Oxaliplatin;
Colon cancer;
Side effects;
Pulmonary fibrosis;
Interstitial lung disease;
D O I:
10.20471/acc.2020.59.04.25
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Oxaliplatin is part of the standard chemotherapy regimens for treating colorectal carcinoma. Pulmonary fibrosis is a serious but rare side effect of oxaliplatin treatment, which resulted in patient death in more than half of the reported cases. The precise pathophysiological mechanism of this phenomenon has not been clarified yet. Analysis of the reported cases strongly suggests that early diagnosis and immediate corticosteroid treatment are crucial for better prognosis. Here we report a case of pulmonary fibrosis related to the FOLFOX regimen in a patient with early colorectal carcinoma.
机构:
UCL, UCL Resp, Lungs Living Res Ctr, London, England
Univ Campania L Vanvitelli, Dept Cardiothorac & Resp Sci, Via L Bianchi, I-80131 Naples, ItalyUCL, UCL Resp, Lungs Living Res Ctr, London, England
Perrotta, Fabio
Bianco, Andrea
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机构:
Univ Campania L Vanvitelli, Dept Cardiothorac & Resp Sci, Via L Bianchi, I-80131 Naples, ItalyUCL, UCL Resp, Lungs Living Res Ctr, London, England
Bianco, Andrea
Cioffi, Giovanni
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机构:
Univ Campania L Vanvitelli, Dept Cardiothorac & Resp Sci, Via L Bianchi, I-80131 Naples, ItalyUCL, UCL Resp, Lungs Living Res Ctr, London, England
Cioffi, Giovanni
Cennamo, Antonio
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机构:
Univ Campania L Vanvitelli, Dept Cardiothorac & Resp Sci, Via L Bianchi, I-80131 Naples, ItalyUCL, UCL Resp, Lungs Living Res Ctr, London, England
Cennamo, Antonio
Mazzarella, Gennaro
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机构:
Univ Campania L Vanvitelli, Dept Cardiothorac & Resp Sci, Via L Bianchi, I-80131 Naples, ItalyUCL, UCL Resp, Lungs Living Res Ctr, London, England
机构:
South China Univ Technol, Gynaecol Affiliated Hosp 6, Sch Med, Foshan, Peoples R ChinaSouth China Univ Technol, Gynaecol Affiliated Hosp 6, Sch Med, Foshan, Peoples R China
Shen, Jiahui
Wen, Zhongyong
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South China Univ Technol, Gynaecol Affiliated Hosp 6, Sch Med, Foshan, Peoples R ChinaSouth China Univ Technol, Gynaecol Affiliated Hosp 6, Sch Med, Foshan, Peoples R China
Wen, Zhongyong
Lin, Jingxia
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South China Univ Technol, Gynaecol Affiliated Hosp 6, Sch Med, Foshan, Peoples R ChinaSouth China Univ Technol, Gynaecol Affiliated Hosp 6, Sch Med, Foshan, Peoples R China
Lin, Jingxia
Su, Huiwen
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South China Univ Technol, Gynaecol Affiliated Hosp 6, Sch Med, Foshan, Peoples R ChinaSouth China Univ Technol, Gynaecol Affiliated Hosp 6, Sch Med, Foshan, Peoples R China