Ginkgetin Inhibits Growth and Invasion of Endometrial Carcinoma by Disruption of Janus Kinase 1/Signal Transducers and Activators of Transcription 3 and Phosphoinositide-3-Kinase/Protein Kinase B Pathways

被引：2
|
作者：
Pan, Shishi [1 ]
Xie, Fengfeng [1 ]
Chen, Wenming [1 ]
Zhai, Qi [1 ]
Zhu, Lili [2 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Obstet, Wenzhou 325000, Zhejiang, Peoples R China
[2] Jingzhou Hosp Tradit Chinese Med, Dept Gynecol, 172 Jiangjin Rd, Jingzhou City 434000, Hubei, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2021年 / 19卷 / 01期
关键词：
Endometrial carcinoma; Ginkgetin; Invasion; JAK1/STAT3; PI3K/AKT; CELL-PROLIFERATION; CANCER CELLS; PI3K/AKT; METASTASIS; APOPTOSIS; BIFLAVONOIDS; PROGRESSION; STATISTICS; SUPPRESSES; STAT3;
D O I：
10.37290/ctnr2641-452X.19:77-83
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Ginkgetin, a bioflavonoid derived from Ginkgo biloba leaves has been shown to promote tumor cell apoptosis and suppress cell growth in a variety of tumors. This study has examined the role and mechanism of ginkgetin on the tumorigenesis of endometrial carcinoma. Results of the studies show that ginkgetin treatment led to a dose-dependent decrease in cell viability, enhanced expression of cleaved caspase-3 protein, and reduced expression of Bcl-2 protein. In addition, cell migration and invasion of HEC1B and Ishikawa cells were repressed by ginkgetin treatment. Levels of phosphoprotein kinase B, Janus kinase 1, and signal transducers and activators of transcription 3 were decreased in HEC1B and Ishikawa cells by ginkgetin treatment. In conclusion, ginkgetin presents with potential for further investigations into its possible role in management of endometrial carcinoma.
引用
收藏
页码：77 / 83
页数：7
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