Ginkgetin Inhibits Growth and Invasion of Endometrial Carcinoma by Disruption of Janus Kinase 1/Signal Transducers and Activators of Transcription 3 and Phosphoinositide-3-Kinase/Protein Kinase B Pathways

Ginkgetin, a bioflavonoid derived from Ginkgo biloba leaves has been shown to promote tumor cell apoptosis and suppress cell growth in a variety of tumors. This study has examined the role and mechanism of ginkgetin on the tumorigenesis of endometrial carcinoma. Results of the studies show that ginkgetin treatment led to a dose-dependent decrease in cell viability, enhanced expression of cleaved caspase-3 protein, and reduced expression of Bcl-2 protein. In addition, cell migration and invasion of HEC1B and Ishikawa cells were repressed by ginkgetin treatment. Levels of phosphoprotein kinase B, Janus kinase 1, and signal transducers and activators of transcription 3 were decreased in HEC1B and Ishikawa cells by ginkgetin treatment. In conclusion, ginkgetin presents with potential for further investigations into its possible role in management of endometrial carcinoma.