A Facile and Practical Synthesis of N-Acetyl Enamides

被引：45
|
作者：
Tang, Wenjun [1 ]
Capacci, Andrew [1 ]
Sarvestani, Max [1 ]
Wei, Xudong [1 ]
Yee, Nathan K. [1 ]
Senanayake, Chris H. [1 ]
机构：
[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Ridgefield, CT 06877 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 24期
关键词：
PALLADIUM-CATALYZED AMIDATION; ASYMMETRIC HYDROGENATION; EFFICIENT SYNTHESIS; ENANTIOSELECTIVE HYDROGENATION;
D O I：
10.1021/jo902259u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and practical method for the synthesis of N-acetyl alpha-arylenamides has been developed from corresponding ketoximes as the starting materials with ferrous acetate as the reducing reagent. This methodology offers mild reaction conditions, simple purification procedures, and high yields for a variety of N-acetyl enamides.
引用
收藏
页码：9528 / 9530
页数：3
相关论文
共 50 条
  • [21] Copper-Catalyzed [3+2] Annulation of 2-Arylidene-1,3-Indandiones with N-Acetyl Enamides for the Synthesis of Spiropyrrolines
    Duan, Jindian
    Mao, Yiyang
    Zhang, Lei
    Zhu, Ning
    Fang, Zheng
    Guo, Kai
    ADVANCED SYNTHESIS & CATALYSIS, 2020, 362 (03) : 695 - 699
  • [22] Facile synthesis of N-2(-F-hexyl) enamides
    Laurent, P
    Ahn, DT
    Blancou, H
    Commeyras, A
    JOURNAL OF FLUORINE CHEMISTRY, 1999, 94 (02) : 139 - 140
  • [23] STATUS OF N-ACETYL CYSTEINE?
    Gold, Joanne
    Marion, Donald
    JOURNAL OF NEUROTRAUMA, 2019, 36 (13) : A78 - A79
  • [24] Synthesis of N-Acetyl Enamides by Reductive Acetylation of Oximes Mediated with Iron(II) Acetate: N-(1-(4-Bromophenyl)vinyl) acetamide
    Tang, Wenjun
    Patel, Nitinchandra D.
    Capacci, Andew G.
    Wei, Xudong
    Yee, Nathan K.
    Senanayake, Chris H.
    Haley, Christopher
    Klare, Hendrik
    Stoltz, Brian
    ORGANIC SYNTHESES, 2013, 90 : 62 - +
  • [25] N-ACETYL GROUPS IN VITELLENIN
    AUGUSTYNIAK, JZ
    MARTIN, WG
    CANADIAN JOURNAL OF BIOCHEMISTRY, 1965, 43 (02): : 291 - +
  • [26] Palladium-Catalyzed Carbonylative Synthesis of N-Acetyl Benzoxazinones
    Qi, Xinxin
    Li, Rui
    Li, Hao-Peng
    Peng, Jin-Bao
    Ying, Jun
    Wu, Xiao-Feng
    CHEMCATCHEM, 2018, 10 (16) : 3415 - 3418
  • [27] N-ACETYL GROUPS AND ANALGESIA
    BALASUBRAMANIAN, AS
    BIOCHEMICAL PHARMACOLOGY, 1981, 30 (12) : 1721 - 1722
  • [28] Synthesis of N-acetyl Glucosamine Analogs as Inhibitors for Hyaluronan Biosynthesis
    Wasonga, Gilbert
    Tatara, Yota
    Kakizaki, Ikuko
    Huang, Xuefei
    JOURNAL OF CARBOHYDRATE CHEMISTRY, 2013, 32 (5-6) : 392 - 409
  • [29] Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs
    Comstock, Lindsay R.
    Denu, John M.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (19) : 3087 - 3091
  • [30] In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla
    Edden, Richard A. E.
    Pomper, Martin G.
    Barker, Peter B.
    MAGNETIC RESONANCE IN MEDICINE, 2007, 57 (06) : 977 - 982
12345