A Facile and Practical Synthesis of N-Acetyl Enamides

被引：45
|
作者：
Tang, Wenjun [1 ]
Capacci, Andrew [1 ]
Sarvestani, Max [1 ]
Wei, Xudong [1 ]
Yee, Nathan K. [1 ]
Senanayake, Chris H. [1 ]
机构：
[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Ridgefield, CT 06877 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 24期
关键词：
PALLADIUM-CATALYZED AMIDATION; ASYMMETRIC HYDROGENATION; EFFICIENT SYNTHESIS; ENANTIOSELECTIVE HYDROGENATION;
D O I：
10.1021/jo902259u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and practical method for the synthesis of N-acetyl alpha-arylenamides has been developed from corresponding ketoximes as the starting materials with ferrous acetate as the reducing reagent. This methodology offers mild reaction conditions, simple purification procedures, and high yields for a variety of N-acetyl enamides.
引用
收藏
页码：9528 / 9530
页数：3
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