Increase expression of gene of differentiation -: E2F4 caused by sulindac derivatives in vitro correlated with apoptosis

被引：0
|
作者：
Rudzki, S [1 ]
Korszen-Pilecka, I
Dudzisz-Sledz, M
Wojcierowski, J
机构：
[1] Med Univ Lublin, Dept Gen & Transplant Surg 1, PL-20950 Lublin, Poland
[2] Med Univ Lublin, Dept Human Genet, PL-20950 Lublin, Poland
来源：
BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY | 2002年
关键词：
sulindac; E(2)F4; pRb; apoptosis; colorectal cancer introduction;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
E(2)F4 gene is a differentiation gene of the cell and the very early transcriptional factor for other genes including E(2)F4 and genes of apoptosis. Overexpression of E(2)F4 gene or decrease of pRB cause cell fast entering S phase of cell cycle and apoptosis. In the presented paper we determine the influence of sulindac sulfide and sulfone derivatives on E(2)F4 expression and apoptosis in LS180 colon carcinoma cells.
引用
收藏
页码：183 / 189
页数：7
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