Extracellular regulated kinase and c-Jun N-terminal kinase are activated in psoriatic involved epidermis

被引：103

作者：

Takahashi, H ^{[1
]}

Ibe, M ^{[1
]}

Nakamura, S ^{[1
]}

Ishida-Yamamoto, A ^{[1
]}

Hashimoto, Y ^{[1
]}

Iizuka, H ^{[1
]}

机构：

[1] Asahikawa Med Coll, Dept Dermatol, Asahikawa, Hokkaido 0788510, Japan

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 2002年 / 30卷 / 02期

关键词：

extracellular regulated kinase; c-Jun N-terminal kinase; mitogen-activated protein kinase; psoriasis;

D O I：

10.1016/S0923-1811(02)00064-6

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriatic skin shows markedly increased keratinocyte proliferation and altered differentiation with various abnormal signalling pathways. In the present study, we investigated the expression of mitogen-activated protein kinases in psoriatic skin. Immunohistochemical study showed increased extracellular regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) expression in the nuclei of involved epidermis. Western blot analyses confirmed the increased active phospho-ERK and phospho-JNK expression in the involved epidermis. In contrast, expression pattern of p38 was not different between the involved and uninvolved epidermis, which was confirmed by western blot analysis. These results indicate that psoriatic epidermis shows selective activation of ERK and JNK, which might be related to hyperproliferation and abnormal differentiation of psoriatic epidermis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：94 / 99

页数：6

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