Apoptosis and chemoresistance in human ovarian cancer: Is Xiap a determinant?

被引：0
|
作者：
Li, JL
Sasaki, H
Sheng, YL
Schneiderman, D
Xiao, CW
Kotsuji, F
Tsang, BK
机构：
[1] Univ Ottawa, Loeb Hlth Res Inst, Ottawa Hosp, Dept Obstet & Gynaecol,Div Gynaecol Oncol, Ottawa, ON K1Y 4E9, Canada
[2] Univ Ottawa, Loeb Hlth Res Inst, Ottawa Hosp, Reprod Biol Unit, Ottawa, ON K1Y 4E9, Canada
[3] Univ Ottawa, Loeb Hlth Res Inst, Ottawa Hosp, Dept Cellular & Mol Med, Ottawa, ON K1Y 4E9, Canada
[4] Fukui Med Univ, Dept Obstet & Gynaecol, Fukui, Japan
来源：
BIOLOGICAL SIGNALS AND RECEPTORS | 2000年 / 9卷 / 02期
关键词：
apoptosis; inhibitor of apoptosis proteins; Fas/Fas ligand; caspases; p53; MDM2; focal adhesion kinase; chemoresistance; human ovarian cancer; gene therapy;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cisplatin-induced apoptosis in epithelial ovarian cancer cells is in part a consequence of suppressed Xiap expression and upregulation of the Fas/FasL system. Changes in the expression of these 'cell death' and 'cell survival' genes lead to activation of caspase-3, and cleavage of MDM2 and FAK, Failure of cancer cells to maintain a balance in the expression of these genes in favor of apoptotic cell death may be an important factor of chemoresistance. Xiap may be a novel target for gene therapy of human ovarian epithelial cancer a nd, dependent on P53 status, expression of Xiap antisense alone or in combination with wild-type P53 sense may offer a new approach for the treatment of the chemoresistant cancer. Copyright (C) 2000 S. Karger AG, Basel.
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收藏
页码：122 / 130
页数：9
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