Apoptosis and chemoresistance in human ovarian cancer: Is Xiap a determinant?

被引：0

作者：

Li, JL

Sasaki, H

Sheng, YL

Schneiderman, D

Xiao, CW

Kotsuji, F

Tsang, BK

机构：

[1] Univ Ottawa, Loeb Hlth Res Inst, Ottawa Hosp, Dept Obstet & Gynaecol,Div Gynaecol Oncol, Ottawa, ON K1Y 4E9, Canada

[2] Univ Ottawa, Loeb Hlth Res Inst, Ottawa Hosp, Reprod Biol Unit, Ottawa, ON K1Y 4E9, Canada

[3] Univ Ottawa, Loeb Hlth Res Inst, Ottawa Hosp, Dept Cellular & Mol Med, Ottawa, ON K1Y 4E9, Canada

[4] Fukui Med Univ, Dept Obstet & Gynaecol, Fukui, Japan

来源：

BIOLOGICAL SIGNALS AND RECEPTORS | 2000年 / 9卷 / 02期

关键词：

apoptosis; inhibitor of apoptosis proteins; Fas/Fas ligand; caspases; p53; MDM2; focal adhesion kinase; chemoresistance; human ovarian cancer; gene therapy;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cisplatin-induced apoptosis in epithelial ovarian cancer cells is in part a consequence of suppressed Xiap expression and upregulation of the Fas/FasL system. Changes in the expression of these 'cell death' and 'cell survival' genes lead to activation of caspase-3, and cleavage of MDM2 and FAK, Failure of cancer cells to maintain a balance in the expression of these genes in favor of apoptotic cell death may be an important factor of chemoresistance. Xiap may be a novel target for gene therapy of human ovarian epithelial cancer a nd, dependent on P53 status, expression of Xiap antisense alone or in combination with wild-type P53 sense may offer a new approach for the treatment of the chemoresistant cancer. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：122 / 130

页数：9

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