Targeting Transcriptional Dependency in Acute Myeloid Leukemia (AML) with a Covalent Inhibitor of Transcriptional Kinase CDK7

被引:0
|
作者
Ren, Yixuan [1 ]
Brown, Victoria [1 ]
Hu, Shanhu [1 ]
Lopez, Jeremy [1 ]
Miljovska, Sofija [1 ]
Schmidt, Darby [1 ]
Bradley, Michael [1 ]
Sprott, Kevin [1 ]
Olson, Eric [1 ]
Fritz, Christian C. [1 ]
Choi, Yoon Jong [1 ]
机构
[1] Syros Pharmaceut, Watertown, MA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [21] Targeting drug-resistant acute myeloid leukemia (AML) clone using casein kinase II inhibitor
    Mercer, Katherine
    Duke, Koby
    Rajaiah, Rajesh
    Daniyal, Muhammad
    Qiu, Yi
    Dovat, Sinisa
    Uzun, Yasin
    Zhang, Lijun
    Huang, Suming
    Klink, Morgann
    Gowda, Chandrika
    CANCER RESEARCH, 2023, 83 (07)
  • [22] Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers
    Sun, Bowen
    Mason, Seth
    Wilson, Robert C.
    Hazard, Starr E.
    Wang, Yubao
    Fang, Rong
    Wang, Qiwei
    Yeh, Elizabeth S.
    Yang, Meixiang
    Roberts, Thomas M.
    Zhao, Jean J.
    Wang, Qi
    ONCOGENE, 2020, 39 (01) : 50 - 63
  • [23] Targeting Super-Enhancer-Associated Oncogenes in Osteosarcoma with THZ2, a Covalent CDK7 Inhibitor
    Zhang, Jiajun
    Liu, Weihai
    Zou, Changye
    Zhao, Zhiqiang
    Lai, Yuanying
    Shi, Zhi
    Xie, Xianbiao
    Huang, Gang
    Wang, Yongqian
    Zhang, Xuelin
    Fan, Zepei
    Su, Qiao
    Yin, Junqiang
    Shen, Jingnan
    CLINICAL CANCER RESEARCH, 2020, 26 (11) : 2681 - 2692
  • [24] Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7
    Hu, Shanhu
    Marineau, Jason J.
    Rajagopal, Nisha
    Hamman, Kristin B.
    Choi, Yoon Jong
    Schmidt, Darby R.
    Ke, Nan
    Johannessen, Liv
    Bradley, Michael J.
    Orlando, David A.
    Alnemy, Sydney R.
    Ren, Yixuan
    Ciblat, Stephane
    Winter, Dana K.
    Kabro, Anzhelika
    Sprott, Kevin T.
    Hodgson, J. Graeme
    Fritz, Christian C.
    Carulli, John P.
    di Tomaso, Emmanuelle
    Olson, Eric R.
    CANCER RESEARCH, 2019, 79 (13) : 3479 - 3491
  • [25] Covalent CDK7 Inhibitor THZ1 Inhibits Myogenic Differentiation
    Ma, Xinqi
    Kuang, Xielan
    Xia, Qing
    Huang, Zixin
    Fan, Yuting
    Ning, Jie
    Wen, Jiajie
    Zhang, Han
    Yan, Jianhua
    Zhang, Qingjiong
    Shen, Huangxuan
    Long, Chongde
    JOURNAL OF CANCER, 2018, 9 (17): : 3149 - 3155
  • [26] Targeting Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia with a Novel Transcriptional Inhibitor
    Maeda, Shintaro
    Morita, Ken
    Suzuki, Kensho
    Sugiyama, Hiroshi
    Adachi, Souichi
    Kamikubo, Yasuhiko
    BLOOD, 2016, 128 (22)
  • [27] Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13
    Zeng, Mei
    Kwiatkowski, Nicholas P.
    Zhang, Tinghu
    Nabet, Behnam
    Xu, Mousheng
    Liang, Yanke
    Quan, Chunshan
    Wang, Jinhua
    Hao, Mingfeng
    Palakurthi, Sangeetha
    Zhou, Shan
    Zeng, Qing
    Kirschmeier, Paul T.
    Meghani, Khyati
    Leggett, Alan L.
    Qi, Jun
    Shapiro, Geoffrey I.
    Liu, Joyce F.
    Matulonis, Ursula A.
    Lin, Charles Y.
    Konstantinopoulos, Panagiotis A.
    Gray, Nathanael S.
    ELIFE, 2018, 7
  • [28] TARGETING MYC AND OTX2-DRIVEN TRANSCRIPTIONAL DEPENDENCIES OF GROUP 3 MEDULLOBLASTOMA THROUGH CDK7 INHIBITION
    Zhang, Lei
    Li, Meng
    Hou, Linjun
    Zhang, Liye
    Tang, Yujie
    NEURO-ONCOLOGY, 2019, 21 : 104 - 104
  • [29] THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours
    Jianyi Sun
    Qiang Zhang
    Xiangfei Sun
    Anwei Xue
    Xiaodong Gao
    Kuntang Shen
    Cell Communication and Signaling, 20
  • [30] Transcriptional and Genomic Characterization of Measurable Residual Disease (MRD) Cells in Acute Myeloid Leukemia (AML)
    Patricia Simoes, Catia
    Villar, Sara
    Ariceta, Benat
    Garces, Juan-Jose
    Burgos, Leire
    Alignani, Diego
    Sarai, Sarvide
    Martinez-Cuadron, David
    Bergua Burgues, Juan Miguel
    Vives, Susana
    Algarra, Lorenzo
    Tormo, Mar
    Martinez Sanchez, Pilar
    Serrano, Josefina
    Herrera, Pilar
    Ramos, Fernando
    Salamero, Olga
    Lavilla, Esperanza
    Gil, Cristina
    Lopez Lorenzo, Jose Luiz
    Belen Vidriales, Maria
    Chillon Santos, Maria Carmen
    Labrador, Jorge
    Falantes, Jose F.
    Jose Sayas, Maria
    Ayala, Rosa
    Martinez-Lopez, Joaquin
    Alfonso-Pierola, Ana
    Jose Calasanz, Maria
    Prosper, Felipe
    San-Miguel, Jesus
    Sanz, Miguel A.
    Montesinos, Pau
    Paiva, Bruno
    BLOOD, 2022, 140 : 2270 - 2272