The Mitochondrial Kinase PINK1 in Diabetic Kidney Disease

被引：14
|
作者：
Huang, Chunling [1 ]
Bian, Ji [1 ]
Cao, Qinghua [1 ]
Chen, Xin-Ming [1 ]
Pollock, Carol A. [1 ]
机构：
[1] Univ Sydney, Rolling Inst, Sydney Med Sch, Royal North Shore Hosp, St Leonards, NSW 2065, Australia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 04期
关键词：
PINK1; diabetic kidney disease; mitochondria; mitochondria quality control; mitophagy;
D O I：
10.3390/ijms22041525
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondria are critical organelles that play a key role in cellular metabolism, survival, and homeostasis. Mitochondrial dysfunction has been implicated in the pathogenesis of diabetic kidney disease. The function of mitochondria is critically regulated by several mitochondrial protein kinases, including the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1). The focus of PINK1 research has been centered on neuronal diseases. Recent studies have revealed a close link between PINK1 and many other diseases including kidney diseases. This review will provide a concise summary of PINK1 and its regulation of mitochondrial function in health and disease. The physiological role of PINK1 in the major cells involved in diabetic kidney disease including proximal tubular cells and podocytes will also be summarized. Collectively, these studies suggested that targeting PINK1 may offer a promising alternative for the treatment of diabetic kidney disease.
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页码：1 / 14
页数：14
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